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Antiretroviral Drug Resistance in HIV-1–Infected Patients Experiencing Persistent Low-Level Viremia During First-Line Therapy

Population sequencing was performed for persons identified with persistent low-level viremia in 2 clinical trials. Persistent low-level viremia (defined as plasma HIV-1 RNA level > 50 and < 1000 copies/mL in at least 2 determinations over a 24-week period, after at least 24 weeks of antiretrov...

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Published in:	The Journal of infectious diseases 2011-08, Vol.204 (4), p.515-520
Main Authors:	Taiwo, Babafemi, Gallien, Sebastien, Aga, Evgenia, Ribaudo, Heather, Haubrich, Richard, Kuritzkes, Daniel R., Eron, Joseph J.
Format:	Article
Language:	English
Subjects:	Adult AIDS Antiretrovirals Biological and medical sciences Drug resistance Drug Resistance, Viral - genetics Female Fundamental and applied biological sciences. Psychology Genetic mutation HIV 1 HIV Infections - blood HIV Infections - drug therapy HIV-1 - drug effects HIV-1 - genetics HIV/AIDS Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Mutation Pretreatment Retrospective Studies Statistical median Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viremia Viremia - blood Viremia - virology Virology
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description	Population sequencing was performed for persons identified with persistent low-level viremia in 2 clinical trials. Persistent low-level viremia (defined as plasma HIV-1 RNA level > 50 and < 1000 copies/mL in at least 2 determinations over a 24-week period, after at least 24 weeks of antiretroviral therapy) was observed in 65 (5.6%) of 1158 patients at risk. New resistance mutations were detected during persistent low-level viremia in 37% of the 54 evaluable cases. The most common mutations were M184I/V (14 cases), K103N (9), and M230L (3). Detection of new mutations was associated with higher HIV-1 RNA levels during persistent low-level viremia.
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Persistent low-level viremia (defined as plasma HIV-1 RNA level > 50 and < 1000 copies/mL in at least 2 determinations over a 24-week period, after at least 24 weeks of antiretroviral therapy) was observed in 65 (5.6%) of 1158 patients at risk. New resistance mutations were detected during persistent low-level viremia in 37% of the 54 evaluable cases. The most common mutations were M184I/V (14 cases), K103N (9), and M230L (3). 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Persistent low-level viremia (defined as plasma HIV-1 RNA level > 50 and < 1000 copies/mL in at least 2 determinations over a 24-week period, after at least 24 weeks of antiretroviral therapy) was observed in 65 (5.6%) of 1158 patients at risk. New resistance mutations were detected during persistent low-level viremia in 37% of the 54 evaluable cases. The most common mutations were M184I/V (14 cases), K103N (9), and M230L (3). Detection of new mutations was associated with higher HIV-1 RNA levels during persistent low-level viremia.</description><subject>Adult</subject><subject>AIDS</subject><subject>Antiretrovirals</subject><subject>Biological and medical sciences</subject><subject>Drug resistance</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic mutation</subject><subject>HIV 1</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - drug therapy</subject><subject>HIV-1 - drug effects</subject><subject>HIV-1 - genetics</subject><subject>HIV/AIDS</subject><subject>Human immunodeficiency virus 1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Major and Brief Reports</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Mutation</subject><subject>Pretreatment</subject><subject>Retrospective Studies</subject><subject>Statistical median</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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source	JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online
subjects	Adult AIDS Antiretrovirals Biological and medical sciences Drug resistance Drug Resistance, Viral - genetics Female Fundamental and applied biological sciences. Psychology Genetic mutation HIV 1 HIV Infections - blood HIV Infections - drug therapy HIV-1 - drug effects HIV-1 - genetics HIV/AIDS Human immunodeficiency virus 1 Human viral diseases Humans Infectious diseases Major and Brief Reports Male Medical sciences Microbiology Mutation Pretreatment Retrospective Studies Statistical median Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viremia Viremia - blood Viremia - virology Virology
title	Antiretroviral Drug Resistance in HIV-1–Infected Patients Experiencing Persistent Low-Level Viremia During First-Line Therapy
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