New methods devised specify the size and color of the spots monkeys see when striate cortex (area V1) is electrically stimulated

• Published in: Proceedings of the National Academy of Sciences - PNAS 2011-10, Vol.108 (43), p.17809-17814
• Main Authors: Schiller, Peter H, Slocum, Warren M, Kwak, Michelle C, Kendall, Geoffrey L, Tehovnik, Edward J
• Format: Article
• Language: English
• Subjects: algorithms; Animals; Biological Sciences; Brain; Brain Mapping - methods; color; Color Perception - physiology; Color Perception - radiation effects; cortex; Electric fields; Electric Stimulation; Electrical stimulation; electrical treatment; Electrodes; Electrodes, Implanted; Eyes; head; humans; Macaca mulatta; Medical equipment; Microelectrodes; monkeys; Monkeys & apes; Neurons; new methods; Perception; Phosphenes; Prostheses and Implants; Prosthetics; Saccades; Saccades - physiology; Sensory perception; vision; Visual cortex; Visual Cortex - physiology; Visual Cortex - radiation effects; Visual Cortex - surgery; Visual fields; Visual Fields - physiology; Visual Fields - radiation effects
• ISSN: 0027-8424; 1091-6490
• DOI: 10.1073/pnas.1108337108

Creating a prosthetic device for the blind is a central future task. Our research examines the feasibility of producing a prosthetic device based on electrical stimulation of primary visual cortex (area V1), an area that remains intact for many years after loss of vision attributable to damage to the eyes. As an initial step in this effort, we believe that the research should be carried out in animals, as it has been in the creation of the highly successful cochlear implant. We chose the rhesus monkey, whose visual system is similar to that of man. We trained monkeys on two tasks to assess the size, contrast, and color of the percepts created when single sites in area V1 are stimulated through microelectrodes. Here, we report that electrical stimulation within the central 5° of the visual field representation creates a small spot that is between 9 and 26 min of arc in diameter and has a contrast ranging between 2.6% and 10%. The dot generated by the stimulation in the majority of cases was darker than the background viewed by the animal and was composed of a variety of low-contrast colors. These findings can be used as inputs to models of electrical stimulation in area V1. On the basis of these findings, we derive what kinds of images would be expected when implanted arrays of electrodes are stimulated through a camera attached to the head whose images are converted into electrical stimulation using appropriate algorithms.