Sleep loss alters synaptic and intrinsic neuronal properties in mouse prefrontal cortex

Abstract Despite sleep-loss-induced cognitive deficits, little is known about the cellular adaptations that occur with sleep loss. We used brain slices obtained from mice that were sleep deprived for 8 h to examine the electrophysiological effects of sleep deprivation (SD). We employed a modified pe...

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Bibliographic Details
Published in:Brain research 2011-10, Vol.1420, p.1-7
Main Authors: Winters, Bradley D, Huang, Yanhua H, Dong, Yan, Krueger, James M
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Analysis of Variance
Animals
Biological and medical sciences
brain
cognition
cortex
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Electric Stimulation
Electroencephalography
EPSC
Excitatory Postsynaptic Potentials - drug effects
Excitatory Postsynaptic Potentials - physiology
Eye Movements
eyes
Flowerpot
Fundamental and applied biological sciences. Psychology
IPSC
Male
Medical sciences
Membrane excitability
Mice
Mice, Inbred C57BL
Nervous system (semeiology, syndromes)
Neurology
Patch-Clamp Techniques
Prefrontal cortex
Prefrontal Cortex - pathology
Pyramidal Cells - drug effects
Pyramidal Cells - physiopathology
Sleep deprivation
Sleep Deprivation - pathology
Sleep Deprivation - physiopathology
Sleep. Vigilance
Synaptic
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Abstract Despite sleep-loss-induced cognitive deficits, little is known about the cellular adaptations that occur with sleep loss. We used brain slices obtained from mice that were sleep deprived for 8 h to examine the electrophysiological effects of sleep deprivation (SD). We employed a modified pedestal (flowerpot) over water method for SD that eliminated rapid eye movement sleep and greatly reduced non-rapid eye movement sleep. In layer V/VI pyramidal cells of the medial prefrontal cortex, miniature excitatory post synaptic current amplitude was slightly reduced, miniature inhibitory post synaptic currents were unaffected, and intrinsic membrane excitability was increased after SD.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2011.08.078