Graft-versus-host disease after kidney transplantation

Graft-versus-host disease (GVHD) is a rare complication after kidney transplantation. We describe a 62-year-old female with end-stage renal disease due to hypertension. She received a kidney with 4 mismatched human leukocyte antigen (HLA) out of 6 HLA - A, B, DR from a deceased donor. After the proc...

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Bibliographic Details
Published in:Journal of the Korean Surgical Society 2011-06, Vol.80 Suppl 1 (Suppl 1), p.S36-S39
Main Authors: Kim, Jong Man, Kim, Sung Joo, Joh, Jae-Won, Kwon, Choon Hyuck David, Jang, Kee-Taek, An, Jungsuk, Ki, Chang-Seok, Kang, Eun-Suk, Shin, Milljae, Kim, Bok Nyeo, Lee, Suk-Koo
Format: Article
Language:English
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Case Report
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Summary:Graft-versus-host disease (GVHD) is a rare complication after kidney transplantation. We describe a 62-year-old female with end-stage renal disease due to hypertension. She received a kidney with 4 mismatched human leukocyte antigen (HLA) out of 6 HLA - A, B, DR from a deceased donor. After the procedure, the patient showed watery diarrhea on postoperative day (POD) 45. An endoscopic biopsy of the colon revealed some apoptotic cells consistent with GVHD. Thrombocytopenia was gradually developed on POD 54. She received steroid pulse therapy, and thrombocytopenia did not progress. However, pneumonia, renal failure, and cardiac failure occurred. She died due to multiple organ failure. We must consider GVHD in renal transplant recipients without homozygous or identical HLA, who had only watery diarrhea without other typical GVHD symptoms such as skin rash and fever, although GVHD is rare in renal transplant recipients.
ISSN:2233-7903
2093-0488
DOI:10.4174/jkss.2011.80.Suppl1.S36