Surrogate Estimates of Insulin Sensitivity in Obese Youth along the Spectrum of Glucose Tolerance from Normal to Prediabetes to Diabetes

Context: In epidemiological studies of childhood obesity, simple and reliable surrogate estimates of insulin sensitivity are needed because the gold standard, the hyperinsulinemic-euglycemic clamp, is not feasible on a large scale. Objective: To examine the correlation of fasting and oral glucose to...

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Bibliographic Details
Published in:The journal of clinical endocrinology and metabolism 2011-07, Vol.96 (7), p.2136-2145
Main Authors: George, Lindsey, Bacha, Fida, Lee, SoJung, Tfayli, Hala, Andreatta, Elisa, Arslanian, Silva
Format: Article
Language:English
Subjects:
Adolescence
Adolescent
Biological and medical sciences
Blood glucose
Blood Glucose - metabolism
Child
Diabetes
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrine Research
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Evaluation
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Glucose Clamp Technique
Glucose Intolerance - metabolism
Glucose Intolerance - physiopathology
Glucose Tolerance Test
Hormones
Humans
Insulin Resistance - physiology
Male
Medical sciences
Obesity
Obesity - metabolism
Obesity - physiopathology
Patients
Prediabetic State - metabolism
Prediabetic State - physiopathology
Research (statistical design)
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vertebrates: endocrinology
Young Adult
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Summary:Context: In epidemiological studies of childhood obesity, simple and reliable surrogate estimates of insulin sensitivity are needed because the gold standard, the hyperinsulinemic-euglycemic clamp, is not feasible on a large scale. Objective: To examine the correlation of fasting and oral glucose tolerance test (OGTT)-derived surrogate indices of insulin sensitivity with the hyperinsulinemic-euglycemic clamp in obese adolescents with normal glucose tolerance, prediabetes, and diabetes. Patients and Design: A total of 188 overweight/obese adolescents (10 to
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2010-2813