Intracellular calcium overloading and oxidative stress in cardiomyocyte necrosis via a mitochondriocentric signal-transducer-effector pathway

• Published in: Experimental and clinical cardiology 2011-12, Vol.16 (4), p.109-115
• Main Authors: Shaheen, Mazen, Cheema, Yaser, Shahbaz, Atta U, Bhattacharya, Syamal K, Weber, Karl T
• Format: Article
• Language: English
• Subjects: Review
• ISSN: 1205-6626; 1918-1515

This article highlights the important scientific contributions of Dr Pawan Singal in the area of cardiomyocyte necrosis such as the importance of intracellular Ca 2+ overloading in mediating cell injury and the pathogenic role of oxidative stress. Parallel to Dr Singal’s findings, the authors also present their own research on a mitochondriocentric signal-transducer-effector pathway to cardiomyocyte necrosis. Understanding these pathogenic origins and pathophysiological expressions of congestive heart failure is paramount to developing medical management strategies. Congestive heart failure (CHF), a common clinical syndrome, has reached epidemic proportions. Its disabling symptoms account for frequent hospitalizations and readmissions. Pathophysiological mechanisms that lead to CHF and account for its progressive nature are of considerable interest. Important scientific observations obtained from Dr Pawan K Singal’s laboratory in Winnipeg, Manitoba, have provided crucial insights to our understanding of the pathophysiological factors that contribute to cardiomyocyte necrosis (the heart is a postmitotic organ incapable of tolerating an ongoing loss of these cells without adverse functional consequences). This increment in knowledge and the mechanistic insights afforded by Dr Singal and his colleagues have highlighted the role of excessive intracellular calcium accumulation and the appearance of oxidative stress in CHF, in which the rate of reactive oxygen species generation overwhelms their rate of detoxification by antioxidant defenses. They have shown that this common pathophysiological scenario applies to diverse entities such as ischemia/reperfusion and hypoxia/reoxygenation forms of injury, myocardial infarction and the cardiomyopathies that accompany diabetes and excess levels of catecholamines and adriamycin. The authors are honoured to be invited to contribute to the present focus issue of Experimental & Clinical Cardiology in recognizing Dr Singal’s numerous scholarly accomplishments. The present article reviews the authors’ recent work on a mitochondriocentric signal-transducer-effector pathway to cardiomyocyte necrosis found in rats with either an acute stressor state that accompanies isoproterenol administration or a chronic stressor state manifested after four weeks of aldosterone/salt treatment.