Synthesis and secretion of gonadotropins including structure-function correlates

The synthesis and secretion of the gonadotropic hormones involves coordination of signal transduction, gene expression, protein translation, post-translational folding and modification and finally secretion. The production of biologically active gonadotropin thus requires appropriately folded and gl...

Full description

Saved in:
Bibliographic Details
Published in:Reviews in endocrine & metabolic disorders 2011-12, Vol.12 (4), p.289-302
Main Authors: Bousfield, George R., Dias, James A.
Format: Article
Language:English
Subjects:
Animals
Carbohydrate Metabolism
Carbohydrate Sequence
Diabetes
Endocrinology
Gene Expression Regulation
Glycosylation
Gonadotropins - genetics
Gonadotropins - metabolism
Gonadotropins - physiology
Humans
Internal Medicine
Medicine
Medicine & Public Health
Models, Molecular
Molecular Sequence Data
Protein Processing, Post-Translational
Structure-Activity Relationship
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The synthesis and secretion of the gonadotropic hormones involves coordination of signal transduction, gene expression, protein translation, post-translational folding and modification and finally secretion. The production of biologically active gonadotropin thus requires appropriately folded and glycosylated subunits that assemble to form the heterodimeric hormone. Here we overview recent literature on regulation of gonadotropin subunit gene expression and current understanding of the assembly and secretion of biologically active gonadotropic hormones. Finally, we discuss the therapeutic potential of understanding glycosylation function towards designing new forms of gonadotropins based on observations of physiologically relevant parameters such as age related glycosylation changes.
ISSN:1389-9155
1573-2606
DOI:10.1007/s11154-011-9191-3