Impact of Diabetes on Postinfarction Heart Failure and Left Ventricular Remodeling

Diabetes mellitus, the metabolic syndrome, and the underlying insulin resistance are increasingly associated with diastolic dysfunction and reduced stress tolerance. The poor prognosis associated with heart failure in patients with diabetes after myocardial infarction is likely attributable to many...

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Bibliographic Details
Published in:Current heart failure reports 2011-12, Vol.8 (4), p.242-251
Main Authors: von Bibra, Helene, St John Sutton, Martin
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Cardiac Surgery
Cardiology
Coronary Circulation
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - metabolism
Diabetes Mellitus, Type 2 - therapy
Endothelium, Vascular - physiopathology
Heart Failure - etiology
Heart Failure - physiopathology
Humans
Imaging
Insulin Resistance
Internal Medicine
Lipid Metabolism
Medicine
Medicine & Public Health
Myocardial Infarction - complications
Myocardium - metabolism
Oxygen Consumption
Prevention of Heart Failure after Myocardial Infarction (Martin St John Sutton
Prevention of Heart Failure after Myocardial Infarction (Martin St John Sutton, Section editor)
Radiology
Section editor
Vascular Surgery
Ventricular Remodeling
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Summary:Diabetes mellitus, the metabolic syndrome, and the underlying insulin resistance are increasingly associated with diastolic dysfunction and reduced stress tolerance. The poor prognosis associated with heart failure in patients with diabetes after myocardial infarction is likely attributable to many factors, important among which is the metabolic impact from insulin resistance and hyperglycemia on the regulation of microvascular perfusion and energy generation in the cardiac myocyte. This review summarizes epidemiologic, pathophysiologic, diagnostic, and therapeutic data related to diabetes and heart failure in acute myocardial infarction and discusses novel perceptions and strategies that hold promise for the future and deserve further investigation.
ISSN:1546-9530
1546-9549
DOI:10.1007/s11897-011-0070-8