Efficacy of premedication with activated Dimethicone or N-acetylcysteine in improving visibility during upper endoscopy

• Published in: World journal of gastroenterology : WJG 2011-10, Vol.17 (37), p.4213-4217
• Main Authors: Asl, Seyed Mohammad Kazem Hosseini, Sivandzadeh, Gholam Reza
• Format: Article
• Language: English
• Subjects: Acetylcysteine; Adult; Aged; Brief; Dimethylpolysiloxanes; Double-Blind Method; Female; Gastroscopy - methods; Humans; Male; Middle Aged; Placebos; Premedication; 乙酰; 二甲基硅油; 内窥镜术; 半胱氨酸; 激活; 用药; 疗效观察; 高能见度
• ISSN: 1007-9327; 2219-2840
• DOI: 10.3748/wjg.v17.i37.4213

AIM：To assess the efficacy of N-acetylcysteine（NAC） and activated Dimethicone in improving endoscopic mucosal visibility.METHODS：A total of 148 patients were randomly allocated into four groups to receive one of the following premedications：group A：100 mL water alone;group B：activated Dimethicone plus water（up to 100 mL）;group C：NAC plus water（up to 100 mL）;and group D：activated Dimethicone and NAC plus water（up to 100 mL）.A single endoscopist blinded to the patients group assessed the gastric mucosal visibility scores（range 1-4） at four sites.The sum of the scores from the four sites was considered as the total mucosal visibility score（TMVS）.RESULTS：The patients in group B showed a significantly lower TMVS than those of groups A and C（P〈0.001）.The TMVS in patients of group D was significantly lower than that of groups A and C（P〈0.001）.The TMVS did not significantly differ between groups B and D（P〉0.05）.The difference between TMVS of groups C and A was not significant（P〉0.05）.CONCLUSION：Premedication with activated Dimethicone 20 min prior to the upper endoscopy leads to the best visibility.NAC does not improve visualization by itself.