A co-twin study of the relative effect of birth weight and gestational age on retinopathy of prematurity

Purpose To determine the relative effect of birth weight and gestational age on retinopathy of prematurity (ROP) using preterm twin pairs discordant for birth weight. Methods This study was a retrospective cohort study including 55 consecutive twin pairs of 110 preterm infants (gestational age ≤33 w...

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Bibliographic Details
Published in:Eye (London) 2011-11, Vol.25 (11), p.1478-1483
Main Authors: Woo, S J, Park, K H, Ahn, J, Oh, K J, Lee, S Y, Jeong, E H
Format: Article
Language:English
Subjects:
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Biological and medical sciences
Birth Weight
Clinical Study
Cohort Studies
Diseases in Twins - epidemiology
Diseases in Twins - pathology
Female
Gestational Age
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Korea - epidemiology
Laboratory Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Miscellaneous
Ophthalmology
Pharmaceutical Sciences/Technology
Retinopathies
Retinopathy of Prematurity - epidemiology
Retinopathy of Prematurity - pathology
Retrospective Studies
Risk Factors
Surgery
Surgical Oncology
Twins
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Summary:Purpose To determine the relative effect of birth weight and gestational age on retinopathy of prematurity (ROP) using preterm twin pairs discordant for birth weight. Methods This study was a retrospective cohort study including 55 consecutive twin pairs of 110 preterm infants (gestational age ≤33 weeks). The outcomes of ROP including occurrence (any stage), severe ROP (stage 3 or more), and clinically significant ROP requiring laser treatment were compared between twins with the lower birth weight from each pair and their co-twins with the higher birth weight. Using twin pairs having different birth weight and identical gestational age, the independent effects of prematurity and intrauterine growth on ROP could be evaluated. Other perinatal morbidities related to prematurity were also compared between twin pairs. Results No significant differences in ROP between larger and smaller infants were observed in the twin-paired analysis while analysis on individual infants showed strong association between small birth weight and ROP outcomes. However, in both the larger and smaller infant groups, gestational age of
ISSN:0950-222X
1476-5454
DOI:10.1038/eye.2011.208