Sensitive Diffusion Tensor Imaging Quantification Method to Identify Language Pathway Abnormalities in Children with Developmental Delay

• Published in: The Journal of pediatrics 2012-01, Vol.160 (1), p.147-151
• Main Authors: Gopal, Sai Prasad, MD, Tiwari, Vijay Narayan, MD, PhD, Veenstra, Amy L., MA, Kumar, Ajay, MD, PhD, Behen, Michael, PhD, Chugani, Harry T., MD, Sundaram, Senthil K., MD
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Brain Mapping - methods; Child; Child, Preschool; children; communication skills; Developmental Disabilities - complications; Diffusion Tensor Imaging; Female; General aspects; Humans; image analysis; Language Development Disorders - diagnosis; Language Development Disorders - etiology; Male; Medical sciences; Neuropsychological Tests; Pediatrics; Sensitivity and Specificity
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2011.06.036

Objective To investigate whether abnormal regional white matter architecture in the perisylvian region could be used as an easy and sensitive quantitative method to demonstrate language pathway abnormalities in children with developmental delay (DD). Study design We performed diffusion tensor imaging in 15 DD subjects (age, 61.1 ± 20.9 months) and 15 age-matched typically developing (TD) children (age, 68.4 ± 19.2 months). With diffusion tensor imaging color-coded orientation maps, we quantified the fraction of fibers in the perisylvian region that are oriented in anteroposterior (AP) and mediolateral (ML) directions, and their ratio (AP/ML) was calculated. Results The AP/ML ratio was more sensitive than tractography in characterizing perisylvian regional abnormalities in DD children. The AP/ML ratio of the left perisylvian region was significantly lower in DD children compared with TD children ( P = .03). The ML component of bilateral perisylvian regions was significantly higher in DD children compared with TD children ( P = .01 [left] and P = .004 [right]). No significant difference was found in the AP component in the two groups. A significant negative correlation of the left ML component with Vineland communication skills was observed (r = −0.657, P = .011). Conclusions The AP/ML ratio appears to be a sensitive indicator of regional white matter architectural abnormalities in the perisylvian region of DD children.