Sjögren's syndrome: studying the disease in mice

Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to stud...

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Bibliographic Details
Published in:Arthritis research & therapy 2011-01, Vol.13 (3), p.217-217
Main Authors: Delaleu, Nicolas, Nguyen, Cuong Q, Peck, Ammon B, Jonsson, Roland
Format: Article
Language:English
Subjects:
Animals
Disease Models, Animal
Humans
Immunogenetics - trends
Mice
Review
Sjogren's Syndrome - genetics
Sjogren's Syndrome - immunology
Sjogren's Syndrome - therapy
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Summary:Sjögren's syndrome (SS), a systemic autoimmune disease, is characterized by inflammation of exocrine tissues accompanied by a significant loss of their secretory function. Clinical symptoms develop late and there are no diagnostic tests enabling early diagnosis of SS. Thus, particularly to study these covert stages, researchers turn to studying animal models where mice provide great freedom for genetic manipulation and testing the effect of experimental intervention. The present review summarizes current literature pertaining to both spontaneous and extrinsic-factor induced SS-like diseases in mouse models, discussing advantages and disadvantages related to the use of murine models in SS research.
ISSN:1478-6354
1478-6362
DOI:10.1186/ar3313