Extracellular Movement of Signaling Molecules

Extracellular signaling molecules have crucial roles in development and homeostasis, and their incorrect deployment can lead to developmental defects and disease states. Signaling molecules are released from sending cells, travel to target cells, and act over length scales of several orders of magni...

Full description

Saved in:
Bibliographic Details
Published in:Developmental cell 2011-07, Vol.21 (1), p.145-158
Main Authors: Müller, Patrick, Schier, Alexander F.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biological Transport
Cell differentiation, maturation, development, hematopoiesis
Cell physiology
Cells - cytology
Cells - metabolism
Endocytosis
Extracellular Matrix - metabolism
Extracellular Space - metabolism
Fundamental and applied biological sciences. Psychology
Humans
Molecular and cellular biology
Movement
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Extracellular signaling molecules have crucial roles in development and homeostasis, and their incorrect deployment can lead to developmental defects and disease states. Signaling molecules are released from sending cells, travel to target cells, and act over length scales of several orders of magnitude, from morphogen-mediated patterning of small developmental fields to hormonal signaling throughout the organism. We discuss how signals are modified and assembled for transport, which routes they take to reach their targets, and how their range is affected by mobility and stability.
ISSN:1534-5807
1878-1551
DOI:10.1016/j.devcel.2011.06.001