Antibiotic susceptibility of Staphylococcus aureus in suppurative lesions in Lacor Hospital, Uganda

Background: Staphylococcus aureus , a mainly acquired hospital infection is responsible for many suppurative lesions and has demonstrated the ability of developing resistance to many antimicrobial agents leading to life threatening infections and long hospital stay. Objective: To determined the prev...

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Bibliographic Details
Published in:African health sciences 2011-08, Vol.11 (3), p.S34-S39
Main Authors: Kitara, LD, Anywar, AD, Acullu, D, Odongo-Aginya, E, Aloyo, J, Fendu, M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Agar
Aged
Aged, 80 and over
Ampicillin
Anti-Bacterial Agents - pharmacology
Antibiotic resistance
Antibiotics
Antimicrobial agents
Blood
Catalase
Child
Child, Preschool
Chloramphenicol
Ciprofloxacin
Co-trimoxazole
Coagulase test
Colonial characteristics
Cross Infection - drug therapy
Cross-Sectional Studies
Diffusion
Drug resistance
Erythromycin
Female
Health and Medicine
Hospitals
Humans
Infant
Infection
Infections
Lesions
Male
Methicillin
Methicillin-Resistant Staphylococcus aureus - drug effects
Middle Aged
Polymerase chain reaction
Risk factors
Salts
Staphylococcal Infections - drug therapy
Staphylococcal Infections - epidemiology
Staphylococcus aureus
Staphylococcus Aureus, antibiotic susceptibility, Lacor Hospital, Gulu
Suppuration - microbiology
Surgery
Tetracyclines
Uganda - epidemiology
Young Adult
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Summary:Background: Staphylococcus aureus , a mainly acquired hospital infection is responsible for many suppurative lesions and has demonstrated the ability of developing resistance to many antimicrobial agents leading to life threatening infections and long hospital stay. Objective: To determined the prevalence and antibiotic susceptibility of Staphylococcus aureus in suppurative lesions of the surgical ward and outpatients of Lacor Hospital (Uganda). Methods: A cross-sectional study was conducted at St. Mary's Hospital Lacor to determine the prevalence and antibiotic susceptibility profiles of Staphylococcus aureus in suppurative lesions in both surgical inpatients and outpatients. Using culture techniques on MacConkey and blood agar, Staphylococcus aureus was isolated based on the colonial characteristics and confirmed by Catalase and tube Coagulase tests. The antibiotic susceptibility test was done using Kirby-Buer disk diffusion method on 4% Salt Muellar Hinton II agar for the Methicillin and non salted Muellar Hinton II agar for the other antibiotics (NCCLS M100S9). Results: The prevalence of Staphylococcus aureus in 122 patients sampled was 59.4% for the surgical inpatients and 48.3% for outpatients giving an average prevalence of 53.9% for both groups of patients. The average antibiotic susceptibility patterns for the 8 antibiotic tested were: Ampicillin (75.0%), Chloramphenicol (34.4%), Ciprofloxacin (1.6%), Erythromycin (7.8%), Gentamycin (0%), Methicillin (1.6%), Tetracycline (45.3%) and Co-trimoxazole (50.0%). The resistance in surgical inpatients was significantly higher than outpatients (t=1299, p
ISSN:1680-6905
1729-0503
1680-6905
DOI:10.4314/ahs.v11i3.70068