Platelets, endothelium and shear join forces to mislead neutrophils in sepsis

Neutrophils are circulating leukocytes with great cytotoxic potential, responsible for the first combat against invading pathogens. Their accumulation in tissues must be highly controlled so that the number of neutrophils delivered to the affected site is sufficient to control infection with minimum...

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Bibliographic Details
Published in:Critical care (London, England) England), 2011-01, Vol.15 (1), p.103-103
Main Authors: Neto, Heitor A Paula, Kubes, Paul
Format: Article
Language:English
Subjects:
Endothelium, Vascular - pathology
Humans
Inflammation Mediators - physiology
Leukocytes - metabolism
Leukocytes - pathology
Sepsis - metabolism
Shear Strength - physiology
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Summary:Neutrophils are circulating leukocytes with great cytotoxic potential, responsible for the first combat against invading pathogens. Their accumulation in tissues must be highly controlled so that the number of neutrophils delivered to the affected site is sufficient to control infection with minimum injury to the surrounding healthy tissue. In sepsis, neutrophil migration is dysregulated - resulting in insufficient delivery of neutrophils to the infectious site and massive neutrophil accumulation in uninfected organs. This dysregulation has the potential to cause inappropriate tissue injury that may explain the multiple organ dysfunction observed in severe sepsis. A better understanding of the mechanisms that contribute to this process is fundamental to design therapeutic strategies to circumvent tissue injury and organ dysfunction in sepsis.
ISSN:1364-8535
1466-609X
DOI:10.1186/cc9371