Exaggerated NMDA Mediated LTD in a Mouse Model of Down Syndrome and Pharmacological Rescuing by Memantine

The Ts65Dn mouse is the best-studied animal model for Down syndrome. In the experiments described here, NMDA-mediated or mGluR-mediated LTD was induced in the CA1 region of hippocampal slices from Ts65Dn and euploid control mice by bath application of 20 [mu]M NMDA for 3 min and 50 [mu]M DHPG for 5...

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Bibliographic Details
Published in:Learning & memory (Cold Spring Harbor, N.Y.) N.Y.), 2011-12, Vol.18 (12), p.774-778
Main Authors: Scott-McKean, Jonah J, Costa, Alberto C. S
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Brain
Brief Communication
Disease Models, Animal
Down Syndrome
Down Syndrome - drug therapy
Down Syndrome - genetics
Down Syndrome - pathology
Drug Therapy
Electric Stimulation
Excitatory Amino Acid Agonists - pharmacology
Excitatory Amino Acid Antagonists - therapeutic use
Excitatory Postsynaptic Potentials - drug effects
Excitatory Postsynaptic Potentials - genetics
Hippocampus - drug effects
Hippocampus - pathology
In Vitro Techniques
Long-Term Synaptic Depression - drug effects
Long-Term Synaptic Depression - genetics
Memantine - therapeutic use
Methoxyhydroxyphenylglycol - analogs & derivatives
Methoxyhydroxyphenylglycol - pharmacology
Mice
Mice, Mutant Strains
N-Methylaspartate - pharmacology
Neurology
Physiology
Time Factors
Trisomy - pathology
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Summary:The Ts65Dn mouse is the best-studied animal model for Down syndrome. In the experiments described here, NMDA-mediated or mGluR-mediated LTD was induced in the CA1 region of hippocampal slices from Ts65Dn and euploid control mice by bath application of 20 [mu]M NMDA for 3 min and 50 [mu]M DHPG for 5 min, respectively. We found that Ts65Dn mice display exaggerated NMDA-induced, but not mGluR-induced, LTD in the CA1 region of the hippocampus compared with euploid control animals. In addition, this abnormal level of LTD can be pharmacologically rescued by the NMDA receptor antagonist memantine.
ISSN:1072-0502
1549-5485
1549-5485
DOI:10.1101/lm.024182.111