The peripheral metabolism of triiodothyronine in normal subjects and in patients with hyperthyroidism

In order to assess the contribution of 3.3',5-triiodo-L-thyronine (T(3)) to overall thyroid hormone economy, conjoint measurements of the kinetics of peripheral T(3) metabolism and the total concentration of T(3) in serum were made in a group of normal subjects and in a group of patients with h...

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Bibliographic Details
Published in:The Journal of clinical investigation 1970-04, Vol.49 (4), p.643-649
Main Authors: Woeber, K A, Sobel, R J, Ingbar, S H, Sterling, K
Format: Article
Language:English
Subjects:
Acetates - pharmacology
Adult
Basal Metabolism
Chemical Precipitation
Chlorine - pharmacology
Female
Graves Disease - drug therapy
Graves Disease - metabolism
Humans
Hyperthyroidism - drug therapy
Hyperthyroidism - metabolism
Kinetics
Male
Methimazole - therapeutic use
Middle Aged
Serum Albumin, Radio-Iodinated
Triiodothyronine - blood
Triiodothyronine - metabolism
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Summary:In order to assess the contribution of 3.3',5-triiodo-L-thyronine (T(3)) to overall thyroid hormone economy, conjoint measurements of the kinetics of peripheral T(3) metabolism and the total concentration of T(3) in serum were made in a group of normal subjects and in a group of patients with hyperthyroid Graves' disease. As judged from the disappearance of trichloroacetic acid-precipitable (131)I from serum after a single intravenous dose of labeled T(3), the following mean values were obtained in the normal subjects: volume of distribution, 43 liters or 0.62 liter/kg; fractional turnover rate. 52% per 24 hr: clearance rate, 22.3 liters/24 hr: and absolute disposal rate, 60 mug/24 hr. In the patients with untreated hyperthyroidism, values for all these functions were greatly increased. After treatment, the volume of T(3) distribution returned to normal but the fractional turnover rate remained abnormally rapid.
ISSN:0021-9738
DOI:10.1172/JCI106275