An Oral-Controlled Release Drug Delivery System for Liquid and Semisolid Drug Formulations

A novel oral drug delivery system for the controlled release of liquid drugs, drug solutions, and semisolid drug preparations is presented that is utilizing the constant vapor pressure of liquefied gas. The system is equipped with a capillary as an element determining the drug delivery rate and cont...

Full description

Saved in:
Bibliographic Details
Published in:AAPS PharmSciTech 2011-12, Vol.12 (4), p.1183-1185
Main Authors: Haznar-Garbacz, Dorota, Garbacz, Grzegorz, Eisenächer, Friederike, Klein, Sandra, Weitschies, Werner
Format: Article
Language:English
Subjects:
Acetaminophen - administration & dosage
Acetaminophen - chemistry
Acrylic Resins - chemistry
Administration, Oral
Analgesics, Non-Narcotic - administration & dosage
Analgesics, Non-Narcotic - chemistry
Biochemistry
Biomedical and Life Sciences
Biomedicine
Biotechnology
Chemistry, Pharmaceutical
Delayed-Action Preparations
Drug Carriers
Drug Compounding
Drug Delivery Systems - instrumentation
Equipment Design
Gases
Gels
Indexing in process
Kinetics
Pentanes - chemistry
Pharmacology/Toxicology
Pharmacy
Rapid Communication
Rheology
Solubility
Technology, Pharmaceutical - methods
Vapor Pressure
Viscosity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A novel oral drug delivery system for the controlled release of liquid drugs, drug solutions, and semisolid drug preparations is presented that is utilizing the constant vapor pressure of liquefied gas. The system is equipped with a capillary as an element determining the drug delivery rate and contains a liquefied propellant with a suitable boiling point below human body temperature. In the dissolution studies, polyacrylate gels of different viscosities containing paracetamol as model drug were used. Zero-order release kinetics was obtained. The release rates were dependent on the gel viscosity. Besides, by gel viscosity, the drug release rates could also be modified by changing the propellant type and the capillary parameters such as length or diameter. Accordingly, the new system enables a wide range of drug delivery kinetics which can be modified in a case-by-case basis in order to match the desired drug delivery characteristics.
ISSN:1530-9932
1530-9932
DOI:10.1208/s12249-011-9689-8