Towards a functional organization of episodic memory in the medial temporal lobe

Here we describe a model of medial temporal lobe organization in which parallel "what" and "where" processing streams converge within the hippocampus to represent events in the spatio-temporal context in which they occurred; this circuitry also mediates the retrieval of context f...

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Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2012-08, Vol.36 (7), p.1597-1608
Main Authors: Eichenbaum, Howard, Sauvage, Magdalena, Fortin, Norbert, Komorowski, Robert, Lipton, Paul
Format: Article
Language:English
Subjects:
Animals
Familiarity
Functional morphology
Hippocampus
Hippocampus - physiology
Humans
Information processing
Memory
Memory, Episodic
Mental Recall - physiology
Nervous system
Neurons - physiology
Recognition (Psychology) - physiology
Reviews
Temporal lobe
Temporal Lobe - physiology
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Summary:Here we describe a model of medial temporal lobe organization in which parallel "what" and "where" processing streams converge within the hippocampus to represent events in the spatio-temporal context in which they occurred; this circuitry also mediates the retrieval of context from event cues and vice versa, which are prototypes of episodic recall. Evidence from studies in animals are reviewed in support of this model, including experiments that distinguish characteristics of episodic recollection from familiarity, neuropsychological and recording studies that have identified a key role for the hippocampus in recollection and in associating events with the context in which they occurred, and distinct roles for parahippocampal region areas in separate "what" and "where" information processing that contributes to recollective and episodic memory.
ISSN:0149-7634
1873-7528
DOI:10.1016/j.neubiorev.2011.07.006