Dendritic SNAREs add a new twist to the old neuron theory

Dendritic exocytosis underpins a broad range of integrative and homeostatic synaptic functions. Emerging data highlight the essential role of SNAREs in trafficking and fusion of secretory organelles with release of peptides and neurotransmitters from dendrites. This Perspective analyzes recent evide...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2011-11, Vol.108 (48), p.19113-19120
Main Authors: Ovsepian, Saak V, Dolly, J. Oliver
Format: Article
Language:English
Subjects:
Calcium - metabolism
Cell membranes
Cell Polarity - physiology
Cells
Data processing
Dendrites
Dendrites - metabolism
Exocytosis
Homeostasis
Membrane Fusion - physiology
Models, Biological
Neurons
Neurons - physiology
Neuroscience
Neurotransmitters
Organelles
Peptides
PERSPECTIVE
Physiological regulation
Polarization
Secretion
SNARE proteins
SNARE Proteins - metabolism
Synapses
Synapses - physiology
Transport Vesicles - metabolism
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Summary:Dendritic exocytosis underpins a broad range of integrative and homeostatic synaptic functions. Emerging data highlight the essential role of SNAREs in trafficking and fusion of secretory organelles with release of peptides and neurotransmitters from dendrites. This Perspective analyzes recent evidence inferring axo-dendritic polarization of vesicular release machinery and pinpoints progress made with existing challenges in this rapidly progressing field of dendritic research. Interpreting the relation of new molecular data to physiological results on secretion from dendrites would greatly advance our understanding of this facet of neuronal mechanisms.
ISSN:0027-8424
1091-6490
1091-6490
DOI:10.1073/pnas.1017235108