Dendritic SNAREs add a new twist to the old neuron theory

Dendritic exocytosis underpins a broad range of integrative and homeostatic synaptic functions. Emerging data highlight the essential role of SNAREs in trafficking and fusion of secretory organelles with release of peptides and neurotransmitters from dendrites. This Perspective analyzes recent evide...

Full description

Saved in:
Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2011-11, Vol.108 (48), p.19113-19120
Main Authors: Ovsepian, Saak V, Dolly, J. Oliver
Format: Article
Language:English
Subjects:
Calcium - metabolism
Cell membranes
Cell Polarity - physiology
Cells
Data processing
Dendrites
Dendrites - metabolism
Exocytosis
Homeostasis
Membrane Fusion - physiology
Models, Biological
Neurons
Neurons - physiology
Neuroscience
Neurotransmitters
Organelles
Peptides
PERSPECTIVE
Physiological regulation
Polarization
Secretion
SNARE proteins
SNARE Proteins - metabolism
Synapses
Synapses - physiology
Transport Vesicles - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c523t-8338fcc60aa32858045fd4ae7a72a1ea285df09fdab791f767d63d64952bd0033
cites cdi_FETCH-LOGICAL-c523t-8338fcc60aa32858045fd4ae7a72a1ea285df09fdab791f767d63d64952bd0033
container_end_page 19120
container_issue 48
container_start_page 19113
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 108
creator Ovsepian, Saak V
Dolly, J. Oliver
description Dendritic exocytosis underpins a broad range of integrative and homeostatic synaptic functions. Emerging data highlight the essential role of SNAREs in trafficking and fusion of secretory organelles with release of peptides and neurotransmitters from dendrites. This Perspective analyzes recent evidence inferring axo-dendritic polarization of vesicular release machinery and pinpoints progress made with existing challenges in this rapidly progressing field of dendritic research. Interpreting the relation of new molecular data to physiological results on secretion from dendrites would greatly advance our understanding of this facet of neuronal mechanisms.
doi_str_mv 10.1073/pnas.1017235108
format article
fullrecord <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3228427</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>23066725</jstor_id><sourcerecordid>23066725</sourcerecordid><originalsourceid>FETCH-LOGICAL-c523t-8338fcc60aa32858045fd4ae7a72a1ea285df09fdab791f767d63d64952bd0033</originalsourceid><addsrcrecordid>eNp9kk1v1DAQhi0EokvhzAmwuMAldMZ2_HFBqtryIVUgUXq2vLHTZpWNt3ZC1X9fR7t0gQMn2zOP3_HMa0JeInxAUPxoM7hcdqgYrxH0I7JAMFhJYeAxWQAwVWnBxAF5lvMKAEyt4Sk5YAw0SFALYk7D4FM3dg29-Hb84yxT5z11dAi3dLzt8kjHSMfrQGPvS3BKcZiPMd09J09a1-fwYrcekstPZz9PvlTn3z9_PTk-r5qa8bHSnOu2aSQ4x5ku5UXdeuGCcoo5DK7EfAum9W6pDLZKKi-5Lw3UbOkBOD8kH7e6m2m5Dr4Jw5hcbzepW7t0Z6Pr7N-Zobu2V_GX5YyV3lUReLcTSPFmCnm06y43oe_dEOKUrQGFopZGFPL9f0lkDFGwWuiCvv0HXcUpDWUQs16pXONc-WgLNSnmnEL78GoEO_tnZ__s3r9y4_WfzT7wvw0rAN0B8829nLZCWzSI88BebZFVHmPaS3CQUrG65N9s862L1l2lLtvLCwYoyv_QiFLwe723sZs</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>907228517</pqid></control><display><type>article</type><title>Dendritic SNAREs add a new twist to the old neuron theory</title><source>JSTOR Archival Journals and Primary Sources Collection</source><source>PubMed Central</source><creator>Ovsepian, Saak V ; Dolly, J. Oliver</creator><creatorcontrib>Ovsepian, Saak V ; Dolly, J. Oliver</creatorcontrib><description>Dendritic exocytosis underpins a broad range of integrative and homeostatic synaptic functions. Emerging data highlight the essential role of SNAREs in trafficking and fusion of secretory organelles with release of peptides and neurotransmitters from dendrites. This Perspective analyzes recent evidence inferring axo-dendritic polarization of vesicular release machinery and pinpoints progress made with existing challenges in this rapidly progressing field of dendritic research. Interpreting the relation of new molecular data to physiological results on secretion from dendrites would greatly advance our understanding of this facet of neuronal mechanisms.</description><identifier>ISSN: 0027-8424</identifier><identifier>ISSN: 1091-6490</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1017235108</identifier><identifier>PMID: 22080607</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Calcium - metabolism ; Cell membranes ; Cell Polarity - physiology ; Cells ; Data processing ; Dendrites ; Dendrites - metabolism ; Exocytosis ; Homeostasis ; Membrane Fusion - physiology ; Models, Biological ; Neurons ; Neurons - physiology ; Neuroscience ; Neurotransmitters ; Organelles ; Peptides ; PERSPECTIVE ; Physiological regulation ; Polarization ; Secretion ; SNARE proteins ; SNARE Proteins - metabolism ; Synapses ; Synapses - physiology ; Transport Vesicles - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2011-11, Vol.108 (48), p.19113-19120</ispartof><rights>copyright © 1993—2008 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Nov 29, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c523t-8338fcc60aa32858045fd4ae7a72a1ea285df09fdab791f767d63d64952bd0033</citedby><cites>FETCH-LOGICAL-c523t-8338fcc60aa32858045fd4ae7a72a1ea285df09fdab791f767d63d64952bd0033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/108/48.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23066725$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23066725$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22080607$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ovsepian, Saak V</creatorcontrib><creatorcontrib>Dolly, J. Oliver</creatorcontrib><title>Dendritic SNAREs add a new twist to the old neuron theory</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Dendritic exocytosis underpins a broad range of integrative and homeostatic synaptic functions. Emerging data highlight the essential role of SNAREs in trafficking and fusion of secretory organelles with release of peptides and neurotransmitters from dendrites. This Perspective analyzes recent evidence inferring axo-dendritic polarization of vesicular release machinery and pinpoints progress made with existing challenges in this rapidly progressing field of dendritic research. Interpreting the relation of new molecular data to physiological results on secretion from dendrites would greatly advance our understanding of this facet of neuronal mechanisms.</description><subject>Calcium - metabolism</subject><subject>Cell membranes</subject><subject>Cell Polarity - physiology</subject><subject>Cells</subject><subject>Data processing</subject><subject>Dendrites</subject><subject>Dendrites - metabolism</subject><subject>Exocytosis</subject><subject>Homeostasis</subject><subject>Membrane Fusion - physiology</subject><subject>Models, Biological</subject><subject>Neurons</subject><subject>Neurons - physiology</subject><subject>Neuroscience</subject><subject>Neurotransmitters</subject><subject>Organelles</subject><subject>Peptides</subject><subject>PERSPECTIVE</subject><subject>Physiological regulation</subject><subject>Polarization</subject><subject>Secretion</subject><subject>SNARE proteins</subject><subject>SNARE Proteins - metabolism</subject><subject>Synapses</subject><subject>Synapses - physiology</subject><subject>Transport Vesicles - metabolism</subject><issn>0027-8424</issn><issn>1091-6490</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp9kk1v1DAQhi0EokvhzAmwuMAldMZ2_HFBqtryIVUgUXq2vLHTZpWNt3ZC1X9fR7t0gQMn2zOP3_HMa0JeInxAUPxoM7hcdqgYrxH0I7JAMFhJYeAxWQAwVWnBxAF5lvMKAEyt4Sk5YAw0SFALYk7D4FM3dg29-Hb84yxT5z11dAi3dLzt8kjHSMfrQGPvS3BKcZiPMd09J09a1-fwYrcekstPZz9PvlTn3z9_PTk-r5qa8bHSnOu2aSQ4x5ku5UXdeuGCcoo5DK7EfAum9W6pDLZKKi-5Lw3UbOkBOD8kH7e6m2m5Dr4Jw5hcbzepW7t0Z6Pr7N-Zobu2V_GX5YyV3lUReLcTSPFmCnm06y43oe_dEOKUrQGFopZGFPL9f0lkDFGwWuiCvv0HXcUpDWUQs16pXONc-WgLNSnmnEL78GoEO_tnZ__s3r9y4_WfzT7wvw0rAN0B8829nLZCWzSI88BebZFVHmPaS3CQUrG65N9s862L1l2lLtvLCwYoyv_QiFLwe723sZs</recordid><startdate>20111129</startdate><enddate>20111129</enddate><creator>Ovsepian, Saak V</creator><creator>Dolly, J. Oliver</creator><general>National Academy of Sciences</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111129</creationdate><title>Dendritic SNAREs add a new twist to the old neuron theory</title><author>Ovsepian, Saak V ; Dolly, J. Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c523t-8338fcc60aa32858045fd4ae7a72a1ea285df09fdab791f767d63d64952bd0033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Calcium - metabolism</topic><topic>Cell membranes</topic><topic>Cell Polarity - physiology</topic><topic>Cells</topic><topic>Data processing</topic><topic>Dendrites</topic><topic>Dendrites - metabolism</topic><topic>Exocytosis</topic><topic>Homeostasis</topic><topic>Membrane Fusion - physiology</topic><topic>Models, Biological</topic><topic>Neurons</topic><topic>Neurons - physiology</topic><topic>Neuroscience</topic><topic>Neurotransmitters</topic><topic>Organelles</topic><topic>Peptides</topic><topic>PERSPECTIVE</topic><topic>Physiological regulation</topic><topic>Polarization</topic><topic>Secretion</topic><topic>SNARE proteins</topic><topic>SNARE Proteins - metabolism</topic><topic>Synapses</topic><topic>Synapses - physiology</topic><topic>Transport Vesicles - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ovsepian, Saak V</creatorcontrib><creatorcontrib>Dolly, J. Oliver</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ovsepian, Saak V</au><au>Dolly, J. Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dendritic SNAREs add a new twist to the old neuron theory</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2011-11-29</date><risdate>2011</risdate><volume>108</volume><issue>48</issue><spage>19113</spage><epage>19120</epage><pages>19113-19120</pages><issn>0027-8424</issn><issn>1091-6490</issn><eissn>1091-6490</eissn><abstract>Dendritic exocytosis underpins a broad range of integrative and homeostatic synaptic functions. Emerging data highlight the essential role of SNAREs in trafficking and fusion of secretory organelles with release of peptides and neurotransmitters from dendrites. This Perspective analyzes recent evidence inferring axo-dendritic polarization of vesicular release machinery and pinpoints progress made with existing challenges in this rapidly progressing field of dendritic research. Interpreting the relation of new molecular data to physiological results on secretion from dendrites would greatly advance our understanding of this facet of neuronal mechanisms.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>22080607</pmid><doi>10.1073/pnas.1017235108</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0027-8424
ispartof Proceedings of the National Academy of Sciences - PNAS, 2011-11, Vol.108 (48), p.19113-19120
issn 0027-8424
1091-6490
1091-6490
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3228427
source JSTOR Archival Journals and Primary Sources Collection; PubMed Central
subjects Calcium - metabolism
Cell membranes
Cell Polarity - physiology
Cells
Data processing
Dendrites
Dendrites - metabolism
Exocytosis
Homeostasis
Membrane Fusion - physiology
Models, Biological
Neurons
Neurons - physiology
Neuroscience
Neurotransmitters
Organelles
Peptides
PERSPECTIVE
Physiological regulation
Polarization
Secretion
SNARE proteins
SNARE Proteins - metabolism
Synapses
Synapses - physiology
Transport Vesicles - metabolism
title Dendritic SNAREs add a new twist to the old neuron theory
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T20%3A01%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dendritic%20SNAREs%20add%20a%20new%20twist%20to%20the%20old%20neuron%20theory&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20-%20PNAS&rft.au=Ovsepian,%20Saak%20V&rft.date=2011-11-29&rft.volume=108&rft.issue=48&rft.spage=19113&rft.epage=19120&rft.pages=19113-19120&rft.issn=0027-8424&rft.eissn=1091-6490&rft_id=info:doi/10.1073/pnas.1017235108&rft_dat=%3Cjstor_pubme%3E23066725%3C/jstor_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c523t-8338fcc60aa32858045fd4ae7a72a1ea285df09fdab791f767d63d64952bd0033%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=907228517&rft_id=info:pmid/22080607&rft_jstor_id=23066725&rfr_iscdi=true