Circulatory and renal consequences of pregnancy in diabetic NOD mice

Abstract Objectives Women with diabetes have elevated gestational risks for severe hemodynamic complications, including preeclampsia in mid- to late pregnancy. This study employed continuous, chronic radiotelemetry to compare the hemodynamic patterns in non-obese diabetic (NOD) mice who were overtly...

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Bibliographic Details
Published in:Placenta (Eastbourne) 2011-12, Vol.32 (12), p.949-955
Main Authors: Burke, S.D, Barrette, V.F, David, S, Khankin, E.V, Adams, M.A, Croy, B.A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Diabetes Mellitus, Type 1 - physiopathology
Embryology: invertebrates and vertebrates. Teratology
Female
Fundamental and applied biological sciences. Psychology
Hemodynamics
Hemodynamics - physiology
Internal Medicine
Kidney - physiopathology
Mice
Mice, Inbred NOD
Obstetrics and Gynecology
Pregnancy
Pregnancy, Animal - physiology
Radiotelemetry
Telemetry
Type 1 diabetes mellitus
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Summary:Abstract Objectives Women with diabetes have elevated gestational risks for severe hemodynamic complications, including preeclampsia in mid- to late pregnancy. This study employed continuous, chronic radiotelemetry to compare the hemodynamic patterns in non-obese diabetic (NOD) mice who were overtly diabetic or normoglycemic throughout gestation. We hypothesized that overtly diabetic, pregnant NOD mice would develop gestational hypertension and provide understanding of mechanisms in progression of this pathology. Study design Telemeter-implanted, age-matched NOD females with and without diabetes were assessed for six hemodynamic parameters (mean, systolic, diastolic, pulse pressures, heart rate and activity) prior to mating, over pregnancy and over a 72 h post-partum interval. Urinalysis, serum biochemistry and renal histopathology were also conducted. Results Pregnant, normoglycemic NOD mice had a hemodynamic profile similar to other inbred strains, despite insulitis. This pattern was characterized by an interval of pre-implantation stability, post implantation decline in arterial pressure to mid gestation, and then a rebound to pre-pregnancy baseline during later gestation. Overtly diabetic NOD mice had a blood pressure profile that was normal until mid-gestation then become mildly hypotensive (−7 mmHg, P  
ISSN:0143-4004
1532-3102
DOI:10.1016/j.placenta.2011.09.018