Thrombospondin 1--a key astrocyte-derived neurogenic factor

Thrombospondin 1 (TSP1), an oligomeric matrix protein, is known for its antiangiogenic activity. Recently, TSP1 has been shown to regulate synaptogenesis in the developing brain. In this study, we examine another role of TSP1 in the CNS, namely, in proliferation and differentiation of neural progeni...

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Bibliographic Details
Published in:The FASEB journal 2010-06, Vol.24 (6), p.1925-1934
Main Authors: Lu, Zhenjie, Kipnis, Jonathan
Format: Article
Language:English
Subjects:
adult neurogenesis
Animals
Astrocytes - metabolism
Blotting, Western
Bromodeoxyuridine
Cell Differentiation
Cell Proliferation
Cells, Cultured
Culture Media, Conditioned - pharmacology
extracellular matrix proteins
Flow Cytometry
Fluorescent Antibody Technique
Immunoenzyme Techniques
Mice
Mice, Inbred C57BL
Mice, Knockout
neural progenitor cells
Neurogenesis - physiology
Neurons - cytology
Neurons - metabolism
oligodendrogenesis
Research Communications
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
Stem Cells - metabolism
Thrombospondin 1 - physiology
Thrombospondins - physiology
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Summary:Thrombospondin 1 (TSP1), an oligomeric matrix protein, is known for its antiangiogenic activity. Recently, TSP1 has been shown to regulate synaptogenesis in the developing brain. In this study, we examine another role of TSP1 in the CNS, namely, in proliferation and differentiation of neural progenitor cells (NPCs). We found that adult mice deficient in TSP1 exhibit reduced proliferation of NPCs in vivo [13,330±826 vs. 4914±455 (mean±SE wt vs. TSP1⁻/⁻); P
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.09-150573