The Role of Triglycerides in Atherosclerosis

Hypertriglyceridemia is a prevalent risk factor for cardiovascular disease (CVD) and increasingly important in the setting of current obesity and insulin resistance epidemics. High triglyceride (TG) levels are markers for several types of atherogenic lipoproteins. Patients who have hypertriglyceride...

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Bibliographic Details
Published in:Current cardiology reports 2011-12, Vol.13 (6), p.544-552
Main Authors: Talayero, Beatriz G., Sacks, Frank M.
Format: Article
Language:English
Subjects:
Atherosclerosis - blood
Atherosclerosis - drug therapy
Atherosclerosis - etiology
Cardiology
Cholesterol, HDL - blood
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - drug therapy
Diabetic Angiopathies - blood
Diabetic Angiopathies - drug therapy
Diabetic Angiopathies - etiology
Humans
Hypertriglyceridemia - blood
Hypertriglyceridemia - complications
Hypertriglyceridemia - drug therapy
Insulin Resistance
Lipid Abnormalities and Cardiovascular Prevention (Michael H. Davidson
Medicine
Medicine & Public Health
Risk Factors
Section Editor
Triglycerides - blood
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Summary:Hypertriglyceridemia is a prevalent risk factor for cardiovascular disease (CVD) and increasingly important in the setting of current obesity and insulin resistance epidemics. High triglyceride (TG) levels are markers for several types of atherogenic lipoproteins. Patients who have hypertriglyceridemia may be at significant risk for CVD even if low-density lipoprotein cholesterol levels are at goal, and therefore warrant treatment that optimizes diet, reduces overweight, and promotes regular exercise. High-risk patients with hypertriglyceridemia, such as those with diabetes, CVD, or metabolic syndrome, may benefit from additional drug treatment aside from a statin to address other lipid abnormalities. In this discussion, we review the role of hypertriglyceridemia and its associated atherogenic lipoproteins in the pathogenesis of atherosclerosis, the relevance of a high TG level as a predictor of CVD, the cardiovascular outcomes from TG-lowering intervention trials, and the current guidelines for treating hypertriglyceridemia.
ISSN:1523-3782
1534-3170
DOI:10.1007/s11886-011-0220-3