A guide to neurotoxic animal models of Parkinson's disease

Parkinson's disease (PD) is a neurological movement disorder primarily resulting from damage to the nigrostriatal dopaminergic pathway. To elucidate the pathogenesis, mechanisms of cell death, and to evaluate therapeutic strategies for PD, numerous animal models have been developed. Understandi...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2011-09, Vol.1 (1), p.a009316-a009316
Main Author: Tieu, Kim
Format: Article
Language:English
Subjects:
Animals
Corpus Striatum - pathology
Corpus Striatum - physiopathology
Disease Models, Animal
Haplorhini
Lewy Bodies - pathology
Mice
MPTP Poisoning - pathology
MPTP Poisoning - physiopathology
Neurotoxins
Oxidopamine
Paraquat
Parkinson Disease - etiology
Parkinson Disease - pathology
Parkinson Disease - physiopathology
Parkinson Disease, Secondary - chemically induced
Parkinson Disease, Secondary - pathology
Parkinson Disease, Secondary - physiopathology
Rats
Rotenone
Substantia Nigra - pathology
Substantia Nigra - physiopathology
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Description
Summary:Parkinson's disease (PD) is a neurological movement disorder primarily resulting from damage to the nigrostriatal dopaminergic pathway. To elucidate the pathogenesis, mechanisms of cell death, and to evaluate therapeutic strategies for PD, numerous animal models have been developed. Understanding the strengths and limitations of these models can significantly impact the choice of model, experimental design, and data interpretation. The primary objectives of this article are twofold: First, to assist new investigators who are contemplating embarking on PD research to navigate through the available animal models. Emphasis will be placed on common neurotoxic murine models in which toxic molecules are used to lesion the nigrostriatal dopaminergic system. And second, to provide an overview of basic technical requirements for assessing the pathology, structure, and function of the nigrostriatal pathway.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a009316