A Rhabdomyosarcoma Arising in the Larynx of a Dog

A neoplastic nodular lesion, 2 x 3 cm in diameter, was found in the larynx of a 6-year-old spayed female dog. The tumor was ill-circumscribed, consisting histologically of large round cells with abundant cytoplasm interspersed with small round cells with less cytoplasm and occasional multinucleated...

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Bibliographic Details
Published in:Journal of Toxicologic Pathology 2011, Vol.24(3), pp.179-182
Main Authors: Yamate, Jyoji, Murai, Fumi, Izawa, Takeshi, Akiyoshi, Hideo, Shimizu, Junichiro, Ohashi, Fumihito, Kuwamura, Mitsuru
Format: Article
Language:English
Subjects:
Case Report
dog
larynx
rhabdomyosarcoma
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Summary:A neoplastic nodular lesion, 2 x 3 cm in diameter, was found in the larynx of a 6-year-old spayed female dog. The tumor was ill-circumscribed, consisting histologically of large round cells with abundant cytoplasm interspersed with small round cells with less cytoplasm and occasional multinucleated cells (myotubes). Immunohistochemically, tumor cells were positive for myoglobin, desmin and vimentin in varying degrees, but negative for S-100 protein, GFAP or cytokeratin. Cytoplasmic myofilaments/myofibrils with a dense Z-line-like structure were seen, the fine structures of which were complemented by PTAH stain. Based on these findings, the tumor was diagnosed as a rhabdomyosarcoma, a very rare tumor in the larynx of dogs.
ISSN:0914-9198
1881-915X
1347-7404
DOI:10.1293/tox.24.179