Human Cu/Zn Superoxide Dismutase Gene Family: Molecular Structure and Characterization of Four Cu/Zn Superoxide Dismutase-Related Pseudogenes

Four distinct human Cu/Zn superoxide dismutase (SOD1; EC 1.15.1.1)-related sequences were isolated from genomic DNA libraries. Genomic blots, heteroduplex analyses, and DNA sequencing showed that they are processed pseudogenes not residing on chromosome 21. Three of them originated from the 0.7-kilo...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1986-06, Vol.83 (11), p.3619-3623
Main Authors: Danciger, Efrat, Dafni, Naomi, Bernstein, Yael, Laver-Rudich, Zehava, Neer, Ada, Groner, Yoram
Format: Article
Language:English
Subjects:
Animals
Bacteriophages
Base Sequence
Biological and medical sciences
Cloning, Molecular
Complementary DNA
Copper
DNA
Fundamental and applied biological sciences. Psychology
Genes
Genes. Genome
Genetic hybridization
Genomics
Humans
Messenger RNA
Mice
Molecular and cellular biology
Molecular genetics
Nucleic Acid Hybridization
Nucleotide sequences
Pseudogenes
Sequence Homology, Nucleic Acid
Superoxide Dismutase - genetics
Superoxides
Zinc
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Summary:Four distinct human Cu/Zn superoxide dismutase (SOD1; EC 1.15.1.1)-related sequences were isolated from genomic DNA libraries. Genomic blots, heteroduplex analyses, and DNA sequencing showed that they are processed pseudogenes not residing on chromosome 21. Three of them originated from the 0.7-kilobase SOD1 mRNA, while the fourth was derived from the 0.9-kilobase mRNA species. Comparison between the coding sequences of the functional gene and two of the processed genes suggested that they integrated into the genome about 25 million years ago.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.83.11.3619