The Effects of a Multiflavonoid Supplement on Vascular and Hemodynamic Parameters following Acute Exercise

• Published in: Oxidative medicine and cellular longevity 2011-01, Vol.2011 (2011), p.1-7
• Main Authors: Collier, Scott R., Nieman, David C., Morris, David, Soukup, Jeffrey, Welsh, Janice, McAnulty, Steven R., Kappus, Rebecca M., Curry, Chelsea D.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Blood Pressure - drug effects; Dietary Supplements; Female; Flavonoids - administration & dosage; Flavonoids - adverse effects; Hemodynamics - drug effects; Humans; Male; Oxidation-Reduction - drug effects; Post-Exercise Hypotension - blood; Post-Exercise Hypotension - drug therapy; Young Adult
• ISSN: 1942-0900; 1942-0994
• DOI: 10.1155/2011/210798

Antioxidants can decrease oxidative stress and combined with acute exercise they may lead to further decreases in blood pressure. The purpose of this study was to investigate the effects of 2 weeks of antioxidant supplementation on vascular distensibility and cardiovascular hemodynamics during postexercise hypotension. Methods. Twenty young subjects were randomized to placebo (n=10) or antioxidant supplementation (n=10) for two weeks. Antioxidant status, vascular distensibility, and hemodynamics were obtained before, immediately, and 30 minutes after an acute bout of aerobic exercise both before and after supplementation. Results. Two weeks of antioxidant supplementation resulted in a greater systolic blood pressure (SBP) decrease during postexercise hypotension (PEH) and significant decreases in augmentation index versus placebo (12.5% versus 3.5%, resp.). Also ferric-reducing ability of plasma (FRAP) increased significantly (interaction P = 0.024) after supplementation. Conclusion. Supplementation showed an additive effect on PEH associated with increased FRAP values and decreases in systolic blood pressure and augmentation index.