Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation

We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent diff...

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Bibliographic Details
Published in:BioMed research international 2011-01, Vol.2011 (2011), p.1-7
Main Authors: Seiler, Katharina, Tsuneto, Motokazu, Melchers, Fritz
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation - physiology
Cellular Reprogramming
Hematopoietic Stem Cells - cytology
Humans
Induced Pluripotent Stem Cells - cytology
Mice
Models, Biological
Review
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Summary:We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent differentiation can generate hematopoietic cell from any somatic cells, it is evident that many of the steps in this process need to be significantly improved before it can be applied to human cells and used in clinical settings of hematopoietic stem cell (HSC) transplantations.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2011/895086