Binding of meso-tetra (4-N-methylpyridyl) porphine to DNA

The porphyrin photosensitizer, meso-Tetra (4-N-methyl-pyridyl) porphine tetraperchlorate is shown to unwind supercoiled Co1EI DNA at a somewhat lower concentration than ethidium bromide. In contrast to this, the Fe(III) chelate of T4MPyP cannot unwind supercoiled DNA. It is concluded that these resu...

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Bibliographic Details
Published in:Nucleic acids research 1980-06, Vol.8 (12), p.2835-2842
Main Authors: Fiel, R.J., Munson, B.R.
Format: Article
Language:English
Subjects:
Chemical Phenomena
Chemistry
DNA, Bacterial
DNA, Superhelical
Escherichia coli
Iron
Mesoporphyrins
Models, Molecular
Molecular Conformation
Nucleic Acid Conformation
Porphyrins
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Summary:The porphyrin photosensitizer, meso-Tetra (4-N-methyl-pyridyl) porphine tetraperchlorate is shown to unwind supercoiled Co1EI DNA at a somewhat lower concentration than ethidium bromide. In contrast to this, the Fe(III) chelate of T4MPyP cannot unwind supercoiled DNA. It is concluded that these results corroborate our previous findings that, despite its large bulk, T4MPyP is fully capable of intercalating in DNA.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/8.12.2835