CD4⁺ T cells mediate mucosal and systemic immune responses to experimental hookworm infection

Hookworm infection is associated with anaemia and malnutrition in many resource-limited countries. Ancylostoma hookworms have previously been shown to modulate host cellular immune responses through multiple mechanisms, including reduced mitogen-mediated lymphocyte proliferation, impaired antigen pr...

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Bibliographic Details
Published in:Parasite immunology 2010-06, Vol.32 (6), p.406-413
Main Authors: DONDJI, B, SUN, T, BUNGIRO, R.D, VERMEIRE, J.J, HARRISON, L.M, BIFULCO, C, CAPPELLO, M
Format: Article
Language:English
Subjects:
Ancylostoma - immunology
Ancylostoma - isolation & purification
Ancylostoma ceylanicum
Ancylostomiasis - immunology
Ancylostomiasis - parasitology
Ancylostomiasis - pathology
anemia
Anemia - parasitology
Animals
Antibodies, Helminth - immunology
Antibodies, Monoclonal - administration & dosage
CD4+ T cells
CD4-Positive T-Lymphocytes - immunology
CD4⁺ T cells
Cricetinae
hookworm
hookworms
Human immunodeficiency virus
Immunity, Mucosal
Intestines - parasitology
Lymphocyte Depletion
Mesocricetus
Nematoda
nematode
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Summary:Hookworm infection is associated with anaemia and malnutrition in many resource-limited countries. Ancylostoma hookworms have previously been shown to modulate host cellular immune responses through multiple mechanisms, including reduced mitogen-mediated lymphocyte proliferation, impaired antigen presentation/processing, and relative reductions in CD4⁺ T cells in the spleen and mesenteric lymph nodes. Syrian hamsters were depleted of CD4⁺ for up to 9 days following intraperitoneal injection (200 μg) of a murine anti-mouse CD4 monoclonal IgG (clone GK1·5). CD4⁺ T-cell-depleted hamsters infected with the hookworm Ancylostoma ceylanicum exhibited a threefold higher mean intestinal worm burden and more severe anaemia than animals that received isotype control IgG. In addition, depletion of CD4⁺ T cells was associated with impaired cellular and humoral (serum and mucosal) immune responses to hookworm antigens. These data demonstrate an effector role for CD4⁺ T cells in hookworm immunity and disease pathogenesis. Ultimately, these studies may yield important insights into the relationship between intestinal nematode infections and diseases that are associated with CD4⁺ T-cell depletion, including HIV.
ISSN:0141-9838
1365-3024
DOI:10.1111/j.1365-3024.2010.01204.x