Nucleotide sequences of nuclear U1A RNAs from chicken, rat and man

The methods of enzymatic and chemical treatment of end-labeled RNA were applied to the determination of the nucleotide sequence of chicken and man U1A RNA and to the reexamination of that of rat U1A RNA. The chemical method allowed the easy demonstration of the cap structure. All three RNA were 165...

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Bibliographic Details
Published in:Nucleic acids research 1980-09, Vol.8 (18), p.4143-4154
Main Authors: Branlant, Christiane, Krol, Alain, Ebel, Jean-Pierre, Lazar, Eliane, Gallinaro, Hélène, Jacob, Monique, Sri-Widada, Joannes, Jeanteur, Philippe
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Brain Chemistry
Cell Nucleus - analysis
Chickens
Codon
Female
HeLa Cells - analysis
Humans
Liver - analysis
Oligoribonucleotides - analysis
Rats
Ribonuclease T1
RNA
Species Specificity
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Summary:The methods of enzymatic and chemical treatment of end-labeled RNA were applied to the determination of the nucleotide sequence of chicken and man U1A RNA and to the reexamination of that of rat U1A RNA. The chemical method allowed the easy demonstration of the cap structure. All three RNA were 165 nucleotide long. Two hither to non described modified pyrimidines were detected close to the 5′ end. Only 9 base substitutions were observed from chicken to man indicating a high degree of conservation of U1A RNA through evolution.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/8.18.4143