Hypothyroidism stimulates D2 receptor-mediated breathing in response to acute hypoxia and alters D2 receptors levels in carotid bodies and brain

Highlights ► Hypothyroidism affects expression of D2 receptors in the PVN, stratum and CB. ► D2 receptor stimulation and hypoxia depressed breathing in normal hamsters. ► D2 receptor stimulation and hypoxia stimulated breathing in hypothyroid hamsters. ► Carotid body and CNS D2 modulation of breathi...

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Bibliographic Details
Published in:Respiratory physiology & neurobiology 2012-01, Vol.180 (1), p.69-78
Main Authors: Schlenker, Evelyn H, Schultz, Harold D
Format: Article
Language:English
Subjects:
Animals
Blotting, Western
Brain - metabolism
Brain - physiopathology
Carotid Body - metabolism
Carotid Body - physiopathology
Cricetinae
Disease Models, Animal
Hypothyroidism - metabolism
Hypothyroidism - physiopathology
Hypoxia - metabolism
Hypoxia - physiopathology
Male
Medical Education
Mesocricetus
Pulmonary/Respiratory
Receptors, Dopamine D2 - biosynthesis
Respiration
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Summary:Highlights ► Hypothyroidism affects expression of D2 receptors in the PVN, stratum and CB. ► D2 receptor stimulation and hypoxia depressed breathing in normal hamsters. ► D2 receptor stimulation and hypoxia stimulated breathing in hypothyroid hamsters. ► Carotid body and CNS D2 modulation of breathing are altered in hypothyroidism.
ISSN:1569-9048
1878-1519
DOI:10.1016/j.resp.2011.10.013