New WAVEs in neuronal PI3K signalling

NYAPs or ‘Neuronal tYrosine‐phosphorylated Adaptor for the PI3K’ are novel regulators of PI3K signalling in neurons. NYAPs link PI3K to the WAVE1 complex to regulate neuronal morphology.

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Bibliographic Details
Published in:The EMBO journal 2011-11, Vol.30 (23), p.4693-4695
Main Authors: Mack, Till G A, Eickholt, Britta J
Format: Article
Language:English
Subjects:
Adaptor Proteins, Signal Transducing
Animals
Brain - pathology
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Humans
Mental disorders
Neocortex
Nervous system
Neurites - pathology
Phosphatidylinositol 3-Kinases - metabolism
Proteins
Wiskott-Aldrich Syndrome Protein Family - metabolism
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Description
Summary:NYAPs or ‘Neuronal tYrosine‐phosphorylated Adaptor for the PI3K’ are novel regulators of PI3K signalling in neurons. NYAPs link PI3K to the WAVE1 complex to regulate neuronal morphology.
ISSN:0261-4189
1460-2075
DOI:10.1038/emboj.2011.405