MINT, the molecular interaction database: 2012 update

The Molecular INTeraction Database (MINT, http://mint.bio.uniroma2.it/mint/) is a public repository for protein-protein interactions (PPI) reported in peer-reviewed journals. The database grows steadily over the years and at September 2011 contains approximately 235 000 binary interactions captured...

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Bibliographic Details
Published in:Nucleic acids research 2012-01, Vol.40 (D1), p.D857-D861
Main Authors: Licata, Luana, Briganti, Leonardo, Peluso, Daniele, Perfetto, Livia, Iannuccelli, Marta, Galeota, Eugenia, Sacco, Francesca, Palma, Anita, Nardozza, Aurelio Pio, Santonico, Elena, Castagnoli, Luisa, Cesareni, Gianni
Format: Article
Language:English
Subjects:
Algorithms
Animals
Databases, Protein
Humans
Mice
Protein Interaction Mapping
Proteins - chemistry
Proteins - genetics
Rats
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Summary:The Molecular INTeraction Database (MINT, http://mint.bio.uniroma2.it/mint/) is a public repository for protein-protein interactions (PPI) reported in peer-reviewed journals. The database grows steadily over the years and at September 2011 contains approximately 235 000 binary interactions captured from over 4750 publications. The web interface allows the users to search, visualize and download interactions data. MINT is one of the members of the International Molecular Exchange consortium (IMEx) and adopts the Molecular Interaction Ontology of the Proteomics Standard Initiative (PSI-MI) standards for curation and data exchange. MINT data are freely accessible and downloadable at http://mint.bio.uniroma2.it/mint/download.do. We report here the growth of the database, the major changes in curation policy and a new algorithm to assign a confidence to each interaction.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkr930