PolymiRTS Database 2.0: linking polymorphisms in microRNA target sites with human diseases and complex traits

The polymorphism in microRNA target site (PolymiRTS) database aims to identify single-nucleotide polymorphisms (SNPs) that affect miRNA targeting in human and mouse. These polymorphisms can disrupt the regulation of gene expression by miRNAs and are candidate genetic variants responsible for transcr...

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Bibliographic Details
Published in:Nucleic acids research 2012-01, Vol.40 (D1), p.D216-D221
Main Authors: Ziebarth, Jesse D., Bhattacharya, Anindya, Chen, Anlong, Cui, Yan
Format: Article
Language:English
Subjects:
Animals
Databases, Nucleic Acid
Disease - genetics
Gene Expression Regulation
Genome-Wide Association Study
Humans
Mice
MicroRNAs - metabolism
Polymorphism, Single Nucleotide
Quantitative Trait Loci
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Summary:The polymorphism in microRNA target site (PolymiRTS) database aims to identify single-nucleotide polymorphisms (SNPs) that affect miRNA targeting in human and mouse. These polymorphisms can disrupt the regulation of gene expression by miRNAs and are candidate genetic variants responsible for transcriptional and phenotypic variation. The database is therefore organized to provide links between SNPs in miRNA target sites, cis-acting expression quantitative trait loci (eQTLs), and the results of genome-wide association studies (GWAS) of human diseases. Here, we describe new features that have been integrated in the PolymiRTS database, including: (i) polymiRTSs in genes associated with human diseases and traits in GWAS, (ii) polymorphisms in target sites that have been supported by a variety of experimental methods and (iii) polymorphisms in miRNA seed regions. A large number of newly identified microRNAs and SNPs, recently published mouse phenotypes, and human and mouse eQTLs have also been integrated into the database. The PolymiRTS database is available at http://compbio.uthsc.edu/miRSNP/.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkr1026