Wiring the oncogenic circuitry: Pin1 unleashes mutant p53

Unlike several tumor suppressor genes, whose inactivation is due to deletions or truncating mutations, TP53 is most frequently hit by missense mutations in its DNA binding domain.

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Bibliographic Details
Published in:Oncotarget 2011-09, Vol.2 (9), p.654-656
Main Authors: Napoli, Marco, Girardini, Javier E, Piazza, Silvano, Del Sal, Giannino
Format: Article
Language:English
Subjects:
Animals
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Female
Humans
Mice
NIMA-Interacting Peptidylprolyl Isomerase
Peptidylprolyl Isomerase - genetics
Peptidylprolyl Isomerase - metabolism
Tumor Suppressor Protein p53 - genetics
Tumor Suppressor Protein p53 - metabolism
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Description
Summary:Unlike several tumor suppressor genes, whose inactivation is due to deletions or truncating mutations, TP53 is most frequently hit by missense mutations in its DNA binding domain.
ISSN:1949-2553
1949-2553
DOI:10.18632/oncotarget.329