Modulation of Specific and Allergy-Related Immune Responses by Helminths

Helminths are master regulators of host immune responses utilising complex mechanisms to dampen host protective Th2-type responses and favour long-term persistence. Such evasion mechanisms ensure mutual survival of both the parasite and the host. In this paper, we present recent findings on the cell...

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Bibliographic Details
Published in:BioMed research international 2011-01, Vol.2011 (2011), p.1-18
Main Authors: Daniłowicz-Luebert, Emilia, O'Regan, Noëlle L., Steinfelder, Svenja, Hartmann, Susanne
Format: Article
Language:English
Subjects:
Animals
B-Lymphocytes - immunology
B-Lymphocytes - parasitology
Chemokines - immunology
Chemokines - metabolism
Cytokines - immunology
Cytokines - metabolism
Dendritic Cells - immunology
Dendritic Cells - parasitology
Helminthiasis - immunology
Helminthiasis - parasitology
Helminths - immunology
Host-Parasite Interactions - immunology
Humans
Hypersensitivity - immunology
Hypersensitivity - parasitology
Immunologic Factors - immunology
Immunomodulation - immunology
Macrophages - immunology
Macrophages - parasitology
Protease Inhibitors - immunology
Protease Inhibitors - metabolism
Review
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - parasitology
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Summary:Helminths are master regulators of host immune responses utilising complex mechanisms to dampen host protective Th2-type responses and favour long-term persistence. Such evasion mechanisms ensure mutual survival of both the parasite and the host. In this paper, we present recent findings on the cells that are targeted by helminths and the molecules and mechanisms that are induced during infection. We discuss the impact of these factors on the host response as well as their effect in preventing the development of aberrant allergic inflammation. We also examine recent findings on helminth-derived molecules that can be used as tools to pinpoint the underlying mechanisms of immune regulation or to determine new anti-inflammatory therapeutics.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2011/821578