Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects

Summary Gene-based association approach could be regarded as a complementary analysis to the single SNP association analysis. We meta-analyzed the findings from the gene-based association approach using the genome-wide association studies (GWAS) data from Chinese and European subjects, confirmed sev...

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Bibliographic Details
Published in:Osteoporosis international 2012-01, Vol.23 (1), p.131-142
Main Authors: Cheung, C.-L., Sham, P.-C., Xiao, S.-M., Bow, C. H., Kung, A. W.-C.
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group - genetics
Association analysis
Bone density
Bone Density - genetics
Bone mineral density
Connective tissues
Data processing
Development
Endocrinology
European Continental Ancestry Group - genetics
Female
Femur Neck - physiology
Gene Regulatory Networks
Genetic Predisposition to Disease
Genome-Wide Association Study
Genomes
Genotype
Hip
Hong Kong - epidemiology
Humans
Iceland - epidemiology
Lumbar Vertebrae - physiology
Medicine
Medicine & Public Health
Meta-analysis
Middle Aged
Original
Original Article
Orthopedics
Osteoporosis
Osteoporosis - ethnology
Osteoporosis - genetics
Osteoporosis - physiopathology
Polymorphism, Single Nucleotide
Reviews
Rheumatology
Signal transduction
Single-nucleotide polymorphism
Spine
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Summary:Summary Gene-based association approach could be regarded as a complementary analysis to the single SNP association analysis. We meta-analyzed the findings from the gene-based association approach using the genome-wide association studies (GWAS) data from Chinese and European subjects, confirmed several well established bone mineral density (BMD) genes, and suggested several novel BMD genes. Introduction The introduction of GWAS has greatly increased the number of genes that are known to be associated with common diseases. Nonetheless, such a single SNP GWAS has a lower power to detect genes with multiple causal variants. We aimed to assess the association of each gene with BMD variation at the spine and hip using gene-based GWAS approach. Methods We studied 778 Hong Kong Southern Chinese (HKSC) women and 5,858 Northern Europeans (dCG); age, sex, and weight were adjusted in the model. The main outcome measure was BMD at the spine and hip. Results Nine genes showed suggestive p value in HKSC, while 4 and 17 genes showed significant and suggestive p values respectively in dCG. Meta-analysis using weighted Z-transformed test confirmed several known BMD genes and suggested some novel ones at 1q21.3, 9q22, 9q33.2, 20p13, and 20q12. Top BMD genes were significantly associated with connective tissue, skeletal, and muscular system development and function ( p  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-011-1779-7