Morphogenesis and the cell cycle

Studies of the processes leading to the construction of a bud and its separation from the mother cell in Saccharomyces cerevisiae have provided foundational paradigms for the mechanisms of polarity establishment, cytoskeletal organization, and cytokinesis. Here we review our current understanding of...

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Bibliographic Details
Published in:Genetics (Austin) 2012-01, Vol.190 (1), p.51-77
Main Authors: Howell, Audrey S, Lew, Daniel J
Format: Article
Language:English
Subjects:
CDC28 Protein Kinase, S cerevisiae - metabolism
Cell cycle
Cell Cycle - physiology
Cell division
Cytokinesis - physiology
Genetics
Morphogenesis - physiology
Morphology
Quorum Sensing
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - growth & development
Yeast
YeastBook
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Summary:Studies of the processes leading to the construction of a bud and its separation from the mother cell in Saccharomyces cerevisiae have provided foundational paradigms for the mechanisms of polarity establishment, cytoskeletal organization, and cytokinesis. Here we review our current understanding of how these morphogenetic events occur and how they are controlled by the cell-cycle-regulatory cyclin-CDK system. In addition, defects in morphogenesis provide signals that feed back on the cyclin-CDK system, and we review what is known regarding regulation of cell-cycle progression in response to such defects, primarily acting through the kinase Swe1p. The bidirectional communication between morphogenesis and the cell cycle is crucial for successful proliferation, and its study has illuminated many elegant and often unexpected regulatory mechanisms. Despite considerable progress, however, many of the most puzzling mysteries in this field remain to be resolved.
ISSN:1943-2631
0016-6731
1943-2631
DOI:10.1534/genetics.111.128314