Myelin Regeneration in Multiple Sclerosis: Targeting Endogenous Stem Cells

Regeneration of myelin sheaths (remyelination) after central nervous system demyelination is important to restore saltatory conduction and to prevent axonal loss. In multiple sclerosis, the insufficiency of remyelination leads to the irreversible degeneration of axons and correlated clinical decline...

Full description

Saved in:
Bibliographic Details
Published in:Neurotherapeutics 2011-10, Vol.8 (4), p.650-658
Main Authors: Huang, Jeffrey K., Fancy, Stephen P. J., Zhao, Chao, Rowitch, David H., ffrench-Constant, Charles, Franklin, Robin J. M.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell cycle
Central Nervous System - cytology
Central Nervous System - metabolism
Humans
Inflammation
Multiple sclerosis
Multiple Sclerosis - physiopathology
Multiple Sclerosis - therapy
Myelin Sheath - metabolism
Nerve Regeneration - drug effects
Nerve Regeneration - physiology
Nervous system
Neurobiology
Neurology
Neurosciences
Neurosurgery
Regenerative medicine
Review
Stem cells
Stem Cells - physiology
Transplants & implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Regeneration of myelin sheaths (remyelination) after central nervous system demyelination is important to restore saltatory conduction and to prevent axonal loss. In multiple sclerosis, the insufficiency of remyelination leads to the irreversible degeneration of axons and correlated clinical decline. Therefore, a regenerative strategy to encourage remyelination may protect axons and improve symptoms in multiple sclerosis. We highlight recent studies on factors that influence endogenous remyelination and potential promising pharmacological targets that may be considered for enhancing central nervous system remyelination.
ISSN:1933-7213
1878-7479
1878-7479
DOI:10.1007/s13311-011-0065-x