Influence of proton pump inhibitor treatment on Helicobacter pylori stool antigen test

AIM： To investigate the effects of proton pump inhibitor （PPI） treatment on stool antigen test using the TestMate pylori enzyme immunoassay. METHODS： This study assessed 28 patients [16 men and 12 women; mean age （63.1 ± 5.9） years; range, 25-84 years] who underwent stool antigen test and urea breat...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2012-01, Vol.18 (1), p.44-48
Main Authors: Kodama, Masaaki, Murakami, Kazunari, Okimoto, Tadayoshi, Fukuda, Yoshihiro, Shimoyama, Tadashi, Okuda, Masumi, Kato, Chieko, Kobayashi, Intetsu, Fujioka, Toshio
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
antigen
Antigens, Bacterial
breath
Breath Tests - methods
Brief
Feces - microbiology
Female
Helicobacter
Helicobacter Infections - diagnosis
Helicobacter Infections - drug therapy
Helicobacter pylori - drug effects
Helicobacter pylori - immunology
Humans
Immunoenzyme Techniques - methods
Immunoenzyme Techniques - standards
inhibitor
Male
Middle Aged
Proton
Proton Pump Inhibitors - therapeutic use
pump
pylori
Sensitivity and Specificity
Stool
test
Urea
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Summary:AIM： To investigate the effects of proton pump inhibitor （PPI） treatment on stool antigen test using the TestMate pylori enzyme immunoassay. METHODS： This study assessed 28 patients [16 men and 12 women; mean age （63.1 ± 5.9） years; range, 25-84 years] who underwent stool antigen test and urea breath test （UBT） before and after PPI administration. RESULTS： Using the UBT as the standard, the sensitivity, specif icity and agreement of the stool antigen test in all 28 patients were 95.2%, 71.4%, and 89.3%, respectively, before PPI administration, and 88.9%, 90.9%, and 89.3%, respectively, after PPI treatment. Mean UBT values were 23.98% ± 5.33% before and 16.19% ± 4.75% after PPI treatment and, in 15 patients treated for ≥ 4 wk, were signif icantly lower after than before 4 wk of PPI treatment （12.58% ± 4.49% vs 24.53% ± 8.53%, P = 0.048）. The mean optical density （A450/630） ratios on the stool antigen test were 1.16 ± 0.20 before and 1.17 ± 0.24 after PPI treatment （P = 0.989）, and were 1.02 ± 0.26 and 0.69 ± 0.28, respectively, in the group treated for 〉 4 wk （P = 0.099）.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v18.i1.44