Receptor for activated C-kinase (RACK1) plays a central role in Ras-mediated signal transduction

SPR experiments demonstrated that B-Raf binds to Ki-Ras forming a complex with RACK1. [...] our present findings establish a direct physical involvement of RACK1 as a scaffold protein in regulating the Ras-Raf-Mek-Erk signaling cascade essential in cancer development.

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Bibliographic Details
Published in:BMC proceedings 2010-09, Vol.4 (S2), p.O10-O10, Article O10
Main Authors: Lillehaug, Johan R, Myklebust, Line M, Raae, Arnt, Bjørndal, Bodil
Format: Article
Language:English
Subjects:
Cancer
Kinases
Medical research
Mutation
Oral Presentation
Signal transduction
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Description
Summary:SPR experiments demonstrated that B-Raf binds to Ki-Ras forming a complex with RACK1. [...] our present findings establish a direct physical involvement of RACK1 as a scaffold protein in regulating the Ras-Raf-Mek-Erk signaling cascade essential in cancer development.
ISSN:1753-6561
1753-6561
DOI:10.1186/1753-6561-4-S2-O10