Methylation of the chicken vitellogenin gene: influence of estradiol administration

The degree of methylation of the chicken vitellogenin gene has been investigated. Upon induction by administration of estradiol to a rooster, methyl groups at specific sites near the 5'-end of the gene are eliminated. The process of demethylation is slower than the activation of the gene. Demet...

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Bibliographic Details
Published in:Nucleic acids research 1983-03, Vol.11 (5), p.1361-1373
Main Authors: Meijlink, F C, Philipsen, J N, Gruber, M, Ab, G
Format: Article
Language:English
Subjects:
Aging
Animals
Chickens - growth & development
Cloning, Molecular
DNA Restriction Enzymes
Estradiol - pharmacology
Female
Genes - drug effects
Lipoproteins - genetics
Liver - drug effects
Liver - metabolism
Male
Methylation
Nucleic Acid Hybridization
Vitellogenins - genetics
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Summary:The degree of methylation of the chicken vitellogenin gene has been investigated. Upon induction by administration of estradiol to a rooster, methyl groups at specific sites near the 5'-end of the gene are eliminated. The process of demethylation is slower than the activation of the gene. Demethylation is therefore probably not a prerequisite to gene transcription. At least two other sites in the coding region of the gene are methylated in the liver of estrogenized roosters, but not in the liver of a laying hen, where the gene is naturally active.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/11.5.1361