Markers of Severe Vaso-Occlusive Painful Episode Frequency in Children and Adolescents with Sickle Cell Anemia

Objective To identify factors associated with frequent severe vaso-occlusive pain crises in a contemporary pediatric cohort of patients with sickle cell anemia (SCA) enrolled in a prospective study of pulmonary hypertension and the hypoxic response in sickle cell disease. Study design Clinical and l...

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Bibliographic Details
Published in:The Journal of pediatrics 2012-02, Vol.160 (2), p.286-290
Main Authors: Darbari, Deepika S., MD, Onyekwere, Onyinye, MD, Nouraie, Mehdi, MD, PhD, Minniti, Caterina P., MD, Luchtman-Jones, Lori, MD, Rana, Sohail, MD, Sable, Craig, MD, Ensing, Gregory, MD, Dham, Niti, MD, Campbell, Andrew, MD, Arteta, Manuel, MD, Gladwin, Mark T., MD, Castro, Oswaldo, MD, Taylor, James G., MD, Kato, Gregory J., MD, Gordeuk, Victor, MD
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
adolescents
Age Factors
alpha-Thalassemia - physiopathology
Anemia, Sickle Cell - blood
Anemia, Sickle Cell - complications
Anemia, Sickle Cell - physiopathology
Anemias. Hemoglobinopathies
Biological and medical sciences
Biomarkers
blood serum
Child
children
Diseases of red blood cells
Female
ferritin
General aspects
health services
Hematologic and hematopoietic diseases
hemoglobin
Hemoglobins - metabolism
Humans
hydroxyurea
hypertension
In Vitro Techniques
iron overload
Iron Overload - physiopathology
L-Lactate Dehydrogenase - blood
lactate dehydrogenase
Male
Medical sciences
pain
Pain - blood
Pain - diagnosis
Pain - etiology
Pain - physiopathology
patients
Pediatrics
Prospective Studies
Risk Factors
Severity of Illness Index
sickle cell anemia
Tricuspid Valve Insufficiency - etiology
Tricuspid Valve Insufficiency - physiopathology
Vascular Diseases - blood
Vascular Diseases - diagnosis
Vascular Diseases - etiology
Vascular Diseases - physiopathology
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Summary:Objective To identify factors associated with frequent severe vaso-occlusive pain crises in a contemporary pediatric cohort of patients with sickle cell anemia (SCA) enrolled in a prospective study of pulmonary hypertension and the hypoxic response in sickle cell disease. Study design Clinical and laboratory characteristics of children with SCA who had ≥3 severe pain crises requiring health care in the preceding year were compared with those of subjects with
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2011.07.018