Aggressive peripheral CD70-positive t-cell lymphoma associated with severe chronic active EBV infection

Severe chronic active Epstein–Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T‐cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show t...

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Bibliographic Details
Published in:Pediatric blood & cancer 2012-10, Vol.59 (4), p.758-761
Main Authors: Shaffer, Donald R., Sheehan, Andrea M., Yi, Zhongzhen, Rodgers, Cheryl C., Bollard, Catherine M., Brenner, Malcolm K., Rooney, Cliona M., Heslop, Helen E., Gottschalk, Stephen
Format: Article
Language:English
Subjects:
CD27 Ligand - metabolism
CD70
Child, Preschool
Chronic Disease
EBV
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - immunology
Epstein-Barr Virus Infections - therapy
Hematopoietic Stem Cell Transplantation
Humans
immunotherapy
lymphoma
Lymphoma, T-Cell - etiology
Lymphoma, T-Cell - immunology
Lymphoma, T-Cell - virology
Male
T-Lymphocytes - immunology
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Summary:Severe chronic active Epstein–Barr virus infection (CAEBV) in T or NK cells is a rare complication of latent EBV infection. CAEBV associated T‐cell lymphoproliferative disease (LPD) consists of polyclonal lesions as well as aggressive lymphomas. Here, we report such a patient. In addition, we show that this primary CAEBV associated T‐cell lymphoma expresses CD70 and is sensitive to killing by CD70‐specific T cells, identifying CD70 as a potential immunotherapeutic target for CAEBV‐associated T‐cell lymphoma. Pediatr Blood Cancer 2012;59:758–761. © 2011 Wiley Periodicals, Inc.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.23352