Small GTPase regulation of GPCR anterograde trafficking

The physiological functions of heterotrimeric G protein-coupled receptors (GPCRs) are dictated by their intracellular trafficking and precise targeting to the functional destinations. Over the past decades, most studies on the trafficking of GPCRs have focused on the events involved in endocytosis a...

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Bibliographic Details
Published in:Trends in pharmacological sciences (Regular ed.) 2012-01, Vol.33 (1), p.28-34
Main Authors: Wang, Guansong, Wu, Guangyu
Format: Article
Language:English
Subjects:
Advanced Basic Science
Endoplasmic Reticulum - metabolism
Humans
Monomeric GTP-Binding Proteins - metabolism
Protein Transport
Receptors, G-Protein-Coupled - metabolism
Signal Transduction
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Summary:The physiological functions of heterotrimeric G protein-coupled receptors (GPCRs) are dictated by their intracellular trafficking and precise targeting to the functional destinations. Over the past decades, most studies on the trafficking of GPCRs have focused on the events involved in endocytosis and recycling. By contrast, the molecular mechanisms underlying anterograde transport of newly synthesized GPCRs from the endoplasmic reticulum (ER) to the cell surface have only now begun to be revealed. In this review we discuss current advances in understanding the role of Ras-like GTPases, specifically the Rab and Sar1/ARF subfamilies, in regulating cell-surface transport of GPCRs en route from the ER and the Golgi.
ISSN:0165-6147
1873-3735
DOI:10.1016/j.tips.2011.09.002