Fluorescent Nanorods and Nanospheres for Real-Time In Vivo Probing of Nanoparticle Shape-Dependent Tumor Penetration

Shape dependent: Fluorescent quantum‐dot‐based nanospheres and nanorods with identical hydrodynamic size and surface properties but different aspect ratios were developed for real‐time in vivo tumor imaging. The nanorods exhibited superior transport and distribution into mammary tumors in vivo versu...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2011-11, Vol.50 (48), p.11417-11420
Main Authors: Chauhan, Vikash P., Popović, Zoran, Chen, Ou, Cui, Jian, Fukumura, Dai, Bawendi, Moungi G., Jain, Rakesh K.
Format: Article
Language:English
Subjects:
Animals
cancer
imaging agents
luminescence
Luminescent Measurements
Metal Nanoparticles - chemistry
Mice
microscopy
Nanomedicine - methods
nanoparticles
Nanoparticles - chemistry
Nanospheres - chemistry
Neoplasms - metabolism
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Summary:Shape dependent: Fluorescent quantum‐dot‐based nanospheres and nanorods with identical hydrodynamic size and surface properties but different aspect ratios were developed for real‐time in vivo tumor imaging. The nanorods exhibited superior transport and distribution into mammary tumors in vivo versus nanospheres of similar plasma half‐life.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201104449