A rhesus macaque model of Streptococcus pneumoniae carriage

Background  Nasopharyngeal colonization by Streptococcus pneumoniae precedes pneumococcal disease. Elucidation of procedures to prevent or eradicate nasopharyngeal carriage in a model akin to the human would help to diminish the incidence of both pneumonia and invasive pneumococcal disease. Methods ...

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Bibliographic Details
Published in:Journal of medical primatology 2012-02, Vol.41 (1), p.60-66
Main Authors: Philipp, M.T., Doyle, L.A., Martin, D.S., Plauché, G.B., Phillippi-Falkenstein, K.M., Bohm Jr, R.P
Format: Article
Language:English
Subjects:
Animals
Breeding
Bronchoalveolar Lavage Fluid - cytology
Bronchoalveolar Lavage Fluid - microbiology
Carrier State - microbiology
Carrier State - veterinary
Colonies
Colonization
Colony Count, Microbial
Infants
Macaca mulatta
Macaca mulatta - microbiology
Male
Microbial Sensitivity Tests
nasopharyngeal carriage
Nasopharynx
Nasopharynx - diagnostic imaging
Nasopharynx - microbiology
Pneumococcal Infections - diagnostic imaging
Pneumococcal Infections - microbiology
Pneumococcal Infections - veterinary
Pneumonia
Radiography
rhesus
Streptococcus pneumoniae
Streptococcus pneumoniae - growth & development
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Summary:Background  Nasopharyngeal colonization by Streptococcus pneumoniae precedes pneumococcal disease. Elucidation of procedures to prevent or eradicate nasopharyngeal carriage in a model akin to the human would help to diminish the incidence of both pneumonia and invasive pneumococcal disease. Methods  We conducted a survey of the nasopharynx of infant rhesus macaques from our breeding colony, in search of natural carriers of S. pneumoniae. We also attempted experimental induction of colonization, by nasopharyngeal instillation of a human S. pneumoniae strain (19F). Results  None of 158 colony animals surveyed carried S. pneumoniae in the nasopharynx. Colonization was induced in eight of eight infant rhesus by nasopharyngeal instillation and lasted 2 weeks in 100% of the animals and 7 weeks in more than 60%. Conclusion  Rhesus macaques are probably not natural carriers of S. pneumoniae. The high rate and duration of colonization obtained in our experiments indicates that the rhesus macaque will serve as a human‐like carriage model.
ISSN:0047-2565
1600-0684
DOI:10.1111/j.1600-0684.2011.00512.x