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A rhesus macaque model of Streptococcus pneumoniae carriage
Background Nasopharyngeal colonization by Streptococcus pneumoniae precedes pneumococcal disease. Elucidation of procedures to prevent or eradicate nasopharyngeal carriage in a model akin to the human would help to diminish the incidence of both pneumonia and invasive pneumococcal disease. Methods ...
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| Published in: | Journal of medical primatology 2012-02, Vol.41 (1), p.60-66 |
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| Main Authors: | , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c5432-d092d571abb51ea3a50dc3a01ca167dd832b437ff6ae10d7d96b71ab70420fe73 |
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| cites | cdi_FETCH-LOGICAL-c5432-d092d571abb51ea3a50dc3a01ca167dd832b437ff6ae10d7d96b71ab70420fe73 |
| container_end_page | 66 |
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| container_start_page | 60 |
| container_title | Journal of medical primatology |
| container_volume | 41 |
| creator | Philipp, M.T. Doyle, L.A. Martin, D.S. Plauché, G.B. Phillippi-Falkenstein, K.M. Bohm Jr, R.P |
| description | Background Nasopharyngeal colonization by Streptococcus pneumoniae precedes pneumococcal disease. Elucidation of procedures to prevent or eradicate nasopharyngeal carriage in a model akin to the human would help to diminish the incidence of both pneumonia and invasive pneumococcal disease.
Methods We conducted a survey of the nasopharynx of infant rhesus macaques from our breeding colony, in search of natural carriers of S. pneumoniae. We also attempted experimental induction of colonization, by nasopharyngeal instillation of a human S. pneumoniae strain (19F).
Results None of 158 colony animals surveyed carried S. pneumoniae in the nasopharynx. Colonization was induced in eight of eight infant rhesus by nasopharyngeal instillation and lasted 2 weeks in 100% of the animals and 7 weeks in more than 60%.
Conclusion Rhesus macaques are probably not natural carriers of S. pneumoniae. The high rate and duration of colonization obtained in our experiments indicates that the rhesus macaque will serve as a human‐like carriage model. |
| doi_str_mv | 10.1111/j.1600-0684.2011.00512.x |
| format | article |
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Methods We conducted a survey of the nasopharynx of infant rhesus macaques from our breeding colony, in search of natural carriers of S. pneumoniae. We also attempted experimental induction of colonization, by nasopharyngeal instillation of a human S. pneumoniae strain (19F).
Results None of 158 colony animals surveyed carried S. pneumoniae in the nasopharynx. Colonization was induced in eight of eight infant rhesus by nasopharyngeal instillation and lasted 2 weeks in 100% of the animals and 7 weeks in more than 60%.
Conclusion Rhesus macaques are probably not natural carriers of S. pneumoniae. The high rate and duration of colonization obtained in our experiments indicates that the rhesus macaque will serve as a human‐like carriage model.</description><identifier>ISSN: 0047-2565</identifier><identifier>EISSN: 1600-0684</identifier><identifier>DOI: 10.1111/j.1600-0684.2011.00512.x</identifier><identifier>PMID: 21967372</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Breeding ; Bronchoalveolar Lavage Fluid - cytology ; Bronchoalveolar Lavage Fluid - microbiology ; Carrier State - microbiology ; Carrier State - veterinary ; Colonies ; Colonization ; Colony Count, Microbial ; Infants ; Macaca mulatta ; Macaca mulatta - microbiology ; Male ; Microbial Sensitivity Tests ; nasopharyngeal carriage ; Nasopharynx ; Nasopharynx - diagnostic imaging ; Nasopharynx - microbiology ; Pneumococcal Infections - diagnostic imaging ; Pneumococcal Infections - microbiology ; Pneumococcal Infections - veterinary ; Pneumonia ; Radiography ; rhesus ; Streptococcus pneumoniae ; Streptococcus pneumoniae - growth & development</subject><ispartof>Journal of medical primatology, 2012-02, Vol.41 (1), p.60-66</ispartof><rights>2011 John Wiley & Sons A/S</rights><rights>2011 John Wiley & Sons A/S.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5432-d092d571abb51ea3a50dc3a01ca167dd832b437ff6ae10d7d96b71ab70420fe73</citedby><cites>FETCH-LOGICAL-c5432-d092d571abb51ea3a50dc3a01ca167dd832b437ff6ae10d7d96b71ab70420fe73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21967372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Philipp, M.T.</creatorcontrib><creatorcontrib>Doyle, L.A.</creatorcontrib><creatorcontrib>Martin, D.S.</creatorcontrib><creatorcontrib>Plauché, G.B.</creatorcontrib><creatorcontrib>Phillippi-Falkenstein, K.M.</creatorcontrib><creatorcontrib>Bohm Jr, R.P</creatorcontrib><title>A rhesus macaque model of Streptococcus pneumoniae carriage</title><title>Journal of medical primatology</title><addtitle>J Med Primatol</addtitle><description>Background Nasopharyngeal colonization by Streptococcus pneumoniae precedes pneumococcal disease. Elucidation of procedures to prevent or eradicate nasopharyngeal carriage in a model akin to the human would help to diminish the incidence of both pneumonia and invasive pneumococcal disease.
Methods We conducted a survey of the nasopharynx of infant rhesus macaques from our breeding colony, in search of natural carriers of S. pneumoniae. We also attempted experimental induction of colonization, by nasopharyngeal instillation of a human S. pneumoniae strain (19F).
Results None of 158 colony animals surveyed carried S. pneumoniae in the nasopharynx. Colonization was induced in eight of eight infant rhesus by nasopharyngeal instillation and lasted 2 weeks in 100% of the animals and 7 weeks in more than 60%.
Conclusion Rhesus macaques are probably not natural carriers of S. pneumoniae. The high rate and duration of colonization obtained in our experiments indicates that the rhesus macaque will serve as a human‐like carriage model.</description><subject>Animals</subject><subject>Breeding</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Bronchoalveolar Lavage Fluid - microbiology</subject><subject>Carrier State - microbiology</subject><subject>Carrier State - veterinary</subject><subject>Colonies</subject><subject>Colonization</subject><subject>Colony Count, Microbial</subject><subject>Infants</subject><subject>Macaca mulatta</subject><subject>Macaca mulatta - microbiology</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>nasopharyngeal carriage</subject><subject>Nasopharynx</subject><subject>Nasopharynx - diagnostic imaging</subject><subject>Nasopharynx - microbiology</subject><subject>Pneumococcal Infections - diagnostic imaging</subject><subject>Pneumococcal Infections - microbiology</subject><subject>Pneumococcal Infections - veterinary</subject><subject>Pneumonia</subject><subject>Radiography</subject><subject>rhesus</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - growth & development</subject><issn>0047-2565</issn><issn>1600-0684</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkc1u1DAUhS0EokPhFVB2sEl6bcd2IhBSNYJS-sNI_O6uHMdpMyTx1E5g-vY4TBnBBuGNLd3vHPnqIyShkNF4jtYZlQApyCLPGFCaAQjKsu09stgP7pMFQK5SJqQ4II9CWAMAz8v8ITlgtJSKK7YgL44Tf23DFJJeG30z2aR3te0S1yQfRm83ozPOmDjeDHbq3dBqmxjtfauv7GPyoNFdsE_u7kPy6c3rj8u36fn7k9Pl8XlqRM5ZWkPJaqGoripBreZaQG24Bmo0laquC86qnKumkdpSqFVdymqmFeQMGqv4IXm1691MVW9rY4fR6w43vu21v0WnW_x7MrTXeOW-I2cSeCliwbO7Au_iimHEvg3Gdp0erJsCllQVQpaMR_L5P0kKDAqRM1lEtNihxrsQvG32H6KAsyVc4ywDZxk4W8JflnAbo0__XGgf_K0lAi93wI-2s7f_XYzvLlbxEePpLt6G0W73ce2_4dwv8MvlCRbL1eXnr-wMV_wn3pGv-w</recordid><startdate>201202</startdate><enddate>201202</enddate><creator>Philipp, M.T.</creator><creator>Doyle, L.A.</creator><creator>Martin, D.S.</creator><creator>Plauché, G.B.</creator><creator>Phillippi-Falkenstein, K.M.</creator><creator>Bohm Jr, R.P</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201202</creationdate><title>A rhesus macaque model of Streptococcus pneumoniae carriage</title><author>Philipp, M.T. ; Doyle, L.A. ; Martin, D.S. ; Plauché, G.B. ; Phillippi-Falkenstein, K.M. ; Bohm Jr, R.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5432-d092d571abb51ea3a50dc3a01ca167dd832b437ff6ae10d7d96b71ab70420fe73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Breeding</topic><topic>Bronchoalveolar Lavage Fluid - cytology</topic><topic>Bronchoalveolar Lavage Fluid - microbiology</topic><topic>Carrier State - microbiology</topic><topic>Carrier State - veterinary</topic><topic>Colonies</topic><topic>Colonization</topic><topic>Colony Count, Microbial</topic><topic>Infants</topic><topic>Macaca mulatta</topic><topic>Macaca mulatta - microbiology</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>nasopharyngeal carriage</topic><topic>Nasopharynx</topic><topic>Nasopharynx - diagnostic imaging</topic><topic>Nasopharynx - microbiology</topic><topic>Pneumococcal Infections - diagnostic imaging</topic><topic>Pneumococcal Infections - microbiology</topic><topic>Pneumococcal Infections - veterinary</topic><topic>Pneumonia</topic><topic>Radiography</topic><topic>rhesus</topic><topic>Streptococcus pneumoniae</topic><topic>Streptococcus pneumoniae - growth & development</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Philipp, M.T.</creatorcontrib><creatorcontrib>Doyle, L.A.</creatorcontrib><creatorcontrib>Martin, D.S.</creatorcontrib><creatorcontrib>Plauché, G.B.</creatorcontrib><creatorcontrib>Phillippi-Falkenstein, K.M.</creatorcontrib><creatorcontrib>Bohm Jr, R.P</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of medical primatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Philipp, M.T.</au><au>Doyle, L.A.</au><au>Martin, D.S.</au><au>Plauché, G.B.</au><au>Phillippi-Falkenstein, K.M.</au><au>Bohm Jr, R.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A rhesus macaque model of Streptococcus pneumoniae carriage</atitle><jtitle>Journal of medical primatology</jtitle><addtitle>J Med Primatol</addtitle><date>2012-02</date><risdate>2012</risdate><volume>41</volume><issue>1</issue><spage>60</spage><epage>66</epage><pages>60-66</pages><issn>0047-2565</issn><eissn>1600-0684</eissn><abstract>Background Nasopharyngeal colonization by Streptococcus pneumoniae precedes pneumococcal disease. Elucidation of procedures to prevent or eradicate nasopharyngeal carriage in a model akin to the human would help to diminish the incidence of both pneumonia and invasive pneumococcal disease.
Methods We conducted a survey of the nasopharynx of infant rhesus macaques from our breeding colony, in search of natural carriers of S. pneumoniae. We also attempted experimental induction of colonization, by nasopharyngeal instillation of a human S. pneumoniae strain (19F).
Results None of 158 colony animals surveyed carried S. pneumoniae in the nasopharynx. Colonization was induced in eight of eight infant rhesus by nasopharyngeal instillation and lasted 2 weeks in 100% of the animals and 7 weeks in more than 60%.
Conclusion Rhesus macaques are probably not natural carriers of S. pneumoniae. The high rate and duration of colonization obtained in our experiments indicates that the rhesus macaque will serve as a human‐like carriage model.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21967372</pmid><doi>10.1111/j.1600-0684.2011.00512.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Wiley:Jisc Collections:Wiley Read and Publish Open Access 2024-2025 (reading list) |
| subjects | Animals Breeding Bronchoalveolar Lavage Fluid - cytology Bronchoalveolar Lavage Fluid - microbiology Carrier State - microbiology Carrier State - veterinary Colonies Colonization Colony Count, Microbial Infants Macaca mulatta Macaca mulatta - microbiology Male Microbial Sensitivity Tests nasopharyngeal carriage Nasopharynx Nasopharynx - diagnostic imaging Nasopharynx - microbiology Pneumococcal Infections - diagnostic imaging Pneumococcal Infections - microbiology Pneumococcal Infections - veterinary Pneumonia Radiography rhesus Streptococcus pneumoniae Streptococcus pneumoniae - growth & development |
| title | A rhesus macaque model of Streptococcus pneumoniae carriage |
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